Loss-of-function mutations in the SCN9A gene encoding voltage-gated sodium channel Na
v 1.7 cause congenital insensitivity to pain in humans and mice. Surprisingly, many potent …

Exposure to moderate levels of ethanol during brain development has a number of effects
on social behavior but the molecular mechanisms that mediate this are not well understood. …

The voltage‐gated sodium channel Na V 1.7 plays a critical role in pain pathways. We
generated an epitope‐tagged Na V 1.7 mouse that showed normal pain behaviours to identify …

Voltage-gated sodium channels (VGSCs) are heteromeric transmembrane protein complexes.
Nine homologous members, SCN1A–11A, make up the VGSC gene family. Sodium …

Descending connections from brainstem nuclei are known to exert powerful control of spinal
nociception and pain behaviours in adult mammals. Here we present evidence that …

Genetic deletion and pharmacological inhibition are distinct approaches to unravelling pain
mechanisms, identifying targets and developing new analgesics. Both approaches have …

Opioid receptors signal more effectively in sensory neurons from pain-free mice lacking the
voltagegated sodium channel Na v 1.7. Type-A GPCRs are known to be regulated through a …

Widespread usage of unmanned aerial vehicles (UAVs) in new and emerging applications
needs dynamic and adaptive networking. The development of routing protocols for UAV ad …

Mobile ad-hoc networks (MANETs) are composed of mobile nodes communicating through
wireless medium, without any fixed centralized infrastructure. Providing quality of service (…

Near surface mounted (NSM) carbon fibers reinforced polymer (CFRP) reinforcement is one
of the techniques for reinforcing masonry structures and is considered to provide significant …