User profiles for A. H. DePace

Angela DePace

Associate Professor of Systems Biology, Harvard Medical School
Verified email at hms.harvard.edu
Cited by 3812

Emerging principles of conformation-based prion inheritance

…, JS Weissman, AH DePace - Annual review of …, 2004 - annualreviews.org
▪ Abstract The prion hypothesis proposes that proteins can act as infectious agents. Originally
formulated to explain transmissible spongiform encephalopathies (TSEs), the prion …

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly

MD Welch, AH DePace, S Verma, A Iwamatsu… - The Journal of cell …, 1997 - rupress.org
The Arp2/3 protein complex has been implicated in the control of actin polymerization in
cells. The human complex consists of seven subunits which include the actin related proteins …

[HTML][HTML] A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion

AH DePace, A Santoso, P Hillner, JS Weissman - Cell, 1998 - cell.com
The yeast [PSI + ] factor propagates by a prion-like mechanism involving self-replicating
Sup35p amyloids. We identified multiple Sup35p mutants that either are poorly recruited into, or …

[HTML][HTML] A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm

…, O Rübel, MY Huang, S Chatoor, AH DePace… - Cell, 2008 - cell.com
To fully understand animal transcription networks, it is essential to accurately measure the
spatial and temporal expression patterns of transcription factors and their targets. We describe …

The appeasement of Doug: a synthetic approach to enhancer biology

BJ Vincent, J Estrada, AH DePace - Integrative Biology, 2016 - academic.oup.com
… of the Department of Systems Biology at Harvard Medical School, the Biological and
Biomedical Science graduate program and current and formers members of the DePace Lab for …

Transcriptional precision and accuracy in development: from measurements to models and mechanisms

L Bentovim, TT Harden, AH DePace - Development, 2017 - journals.biologists.com
During development, genes are transcribed at specific times, locations and levels. In recent
years, the emergence of quantitative tools has significantly advanced our ability to measure …

[BOOK][B] Visual strategies: A practical guide to graphics for scientists & engineers

F Frankel, AH DePace - 2012 - books.google.com
… Visual communicator Felice Frankel and systems biologist Angela DePace, along with …
DePace is an assistant professor in the Department of Systems Biology at Harvard Medical School…

[HTML][HTML] Three-dimensional morphology and gene expression in the Drosophilablastoderm at cellular resolution I: data acquisition pipeline

…, CC Fowlkes, L Simirenko, GH Weber, AH DePace… - Genome biology, 2006 - Springer
Background To model and thoroughly understand animal transcription networks, it is
essential to derive accurate spatial and temporal descriptions of developing gene expression …

Depleting Gene Activities in Early Drosophila Embryos with the “Maternal-Gal4–shRNA” System

…, ZB Wunderlich, R Tao, LA Perkins, AH DePace… - Genetics, 2013 - academic.oup.com
In a developing Drosophila melanogaster embryo, mRNAs have a maternal origin, a zygotic
origin, or both. During the maternal–zygotic transition, maternal products are degraded and …

Origins and kinetic consequences of diversity in Sup35 yeast prion fibers

AH DePace, JS Weissman - Nature structural biology, 2002 - nature.com
A remarkable feature of prions is that infectious particles composed of the same prion protein
can give rise to different phenotypes. This strain phenomenon suggests that a single prion …