User profiles for A. H. DePace
Angela DePaceAssociate Professor of Systems Biology, Harvard Medical School Verified email at hms.harvard.edu Cited by 3812 |
Emerging principles of conformation-based prion inheritance
…, JS Weissman, AH DePace - Annual review of …, 2004 - annualreviews.org
▪ Abstract The prion hypothesis proposes that proteins can act as infectious agents. Originally
formulated to explain transmissible spongiform encephalopathies (TSEs), the prion …
formulated to explain transmissible spongiform encephalopathies (TSEs), the prion …
The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly
The Arp2/3 protein complex has been implicated in the control of actin polymerization in
cells. The human complex consists of seven subunits which include the actin related proteins …
cells. The human complex consists of seven subunits which include the actin related proteins …
[HTML][HTML] A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion
AH DePace, A Santoso, P Hillner, JS Weissman - Cell, 1998 - cell.com
The yeast [PSI + ] factor propagates by a prion-like mechanism involving self-replicating
Sup35p amyloids. We identified multiple Sup35p mutants that either are poorly recruited into, or …
Sup35p amyloids. We identified multiple Sup35p mutants that either are poorly recruited into, or …
[HTML][HTML] A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
To fully understand animal transcription networks, it is essential to accurately measure the
spatial and temporal expression patterns of transcription factors and their targets. We describe …
spatial and temporal expression patterns of transcription factors and their targets. We describe …
The appeasement of Doug: a synthetic approach to enhancer biology
… of the Department of Systems Biology at Harvard Medical School, the Biological and
Biomedical Science graduate program and current and formers members of the DePace Lab for …
Biomedical Science graduate program and current and formers members of the DePace Lab for …
Transcriptional precision and accuracy in development: from measurements to models and mechanisms
L Bentovim, TT Harden, AH DePace - Development, 2017 - journals.biologists.com
During development, genes are transcribed at specific times, locations and levels. In recent
years, the emergence of quantitative tools has significantly advanced our ability to measure …
years, the emergence of quantitative tools has significantly advanced our ability to measure …
[BOOK][B] Visual strategies: A practical guide to graphics for scientists & engineers
F Frankel, AH DePace - 2012 - books.google.com
… Visual communicator Felice Frankel and systems biologist Angela DePace, along with …
DePace is an assistant professor in the Department of Systems Biology at Harvard Medical School…
DePace is an assistant professor in the Department of Systems Biology at Harvard Medical School…
[HTML][HTML] Three-dimensional morphology and gene expression in the Drosophilablastoderm at cellular resolution I: data acquisition pipeline
Background To model and thoroughly understand animal transcription networks, it is
essential to derive accurate spatial and temporal descriptions of developing gene expression …
essential to derive accurate spatial and temporal descriptions of developing gene expression …
Depleting Gene Activities in Early Drosophila Embryos with the “Maternal-Gal4–shRNA” System
…, ZB Wunderlich, R Tao, LA Perkins, AH DePace… - Genetics, 2013 - academic.oup.com
In a developing Drosophila melanogaster embryo, mRNAs have a maternal origin, a zygotic
origin, or both. During the maternal–zygotic transition, maternal products are degraded and …
origin, or both. During the maternal–zygotic transition, maternal products are degraded and …
Origins and kinetic consequences of diversity in Sup35 yeast prion fibers
AH DePace, JS Weissman - Nature structural biology, 2002 - nature.com
A remarkable feature of prions is that infectious particles composed of the same prion protein
can give rise to different phenotypes. This strain phenomenon suggests that a single prion …
can give rise to different phenotypes. This strain phenomenon suggests that a single prion …