We introduce two large-scale resources for functional analysis of microRNA (miRNA): a decoy
library for inhibiting miRNA function and a sensor library for monitoring microRNA activity. …

Deep sequencing of small RNAs (sRNA-seq) is now the gold standard for small RNA
profiling and discovery. Biases in sRNA-seq have been reported, but their etiology remains …

Considerable details about microRNA (miRNA) biogenesis and regulation have been uncovered,
but little is known about the fate of the miRNA subsequent to target regulation. To gain …

Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are
ostensibly decoupled in their replication, segregation and inheritance. It is increasingly …

In ∼30% of patients with EGFR-mutant lung adenocarcinomas whose disease progresses
on EGFR inhibitors, the basis for acquired resistance remains unclear. We have integrated …

Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear
reprogramming, and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem …

The coronavirus disease 2019 (COVID-19) pandemic has highlighted bottlenecks in large-scale,
frequent testing of populations for infections. Polymerase chain reaction (PCR)-based …

… Efforts are now underway to harness embryonic stem cells and to take advantage of this
promising capability, with the goal of devising new and more effective treatments for a host of …

Swine represent the only livestock with an established invariant NKT (iNKT) cell–CD1d
system. In this study, we exploited the fact that pig iNKT cells can be purified using a mouse …

Mycobacterium kansasii (Mk) is a resilient opportunistic human pathogen that causes
tuberculosis‐like chronic pulmonary disease and mortality stemming from comorbidities and …