User profiles for A. D. Hargreaves

Adam Hargreaves

Sir Henry Wellcome Postdoctoral Fellow, University of Oxford
Verified email at zoo.ox.ac.uk
Cited by 1039

Chromatin changes in apoptosis

AH Wyllie, GJ Beattie, AD Hargreaves - The Histochemical Journal, 1981 - Springer
Murine lymphoid cell lines and rat thymocytes treatedin vitro with glucocorticoid hormones
provide a convenient system for studying the nuclear changes in apoptosis. Morphologically …

Restriction and recruitment—gene duplication and the origin and evolution of snake venom toxins

AD Hargreaves, MT Swain, MJ Hegarty… - Genome biology and …, 2014 - academic.oup.com
Snake venom has been hypothesized to have originated and diversified through a process
that involves duplication of genes encoding body proteins with subsequent recruitment of the …

Hormone-induced cell death. 2. Surface changes in thymocytes undergoing apoptosis.

RG Morris, AD Hargreaves, E Duvall… - The American journal of …, 1984 - ncbi.nlm.nih.gov
In vivo, apoptotic cells are swiftly recognized by phagocytes, presumably because of
changes on their surface. This article describes surface changes in rat cortical thymocytes …

Testing the Toxicofera: comparative transcriptomics casts doubt on the single, early evolution of the reptile venom system

AD Hargreaves, MT Swain, DW Logan, JF Mulley - Toxicon, 2014 - Elsevier
The identification of apparently conserved gene complements in the venom and salivary
glands of a diverse set of reptiles led to the development of the Toxicofera hypothesis – the …

[HTML][HTML] Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed …

…, MC Williams, AD Flapan, JF Forbes, AD Hargreaves… - Trials, 2012 - Springer
Background Rapid access chest pain clinics have facilitated the early diagnosis and
treatment of patients with coronary heart disease and angina. Despite this important service …

[HTML][HTML] Assessing the utility of the Oxford Nanopore MinION for snake venom gland cDNA sequencing

AD Hargreaves, JF Mulley - PeerJ, 2015 - peerj.com
Portable DNA sequencers such as the Oxford Nanopore MinION device have the potential
to be truly disruptive technologies, facilitating new approaches and analyses and, in some …

[HTML][HTML] Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate …

JF Mulley, AD Hargreaves, MJ Hegarty, RS Heller… - BMC genomics, 2014 - Springer
Background Understanding the evolution of the vertebrate pancreas is key to understanding
its functions. The chondrichthyes (cartilaginous fish such as sharks and rays) have often …

A randomised controlled trial of senior Lay Health Mentoring in older people with ischaemic heart disease: The Braveheart Project

…, R Elton, PS Murdoch, AD Hargreaves - Age and …, 2004 - academic.oup.com
Objective: to examine the effects and feasibility of educating and empowering older people
with ischaemic heart disease using trained senior lay health mentors. Design: randomised …

Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster

AD Hargreaves, L Zhou… - Proceedings of the …, 2017 - National Acad Sciences
The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and
the Middle East, and is constrained in its ecology because high carbohydrate diets induce …

[PDF][PDF] Runaway GC evolution in gerbil genomes

R Pracana, AD Hargreaves, JF Mulley… - … Biology and Evolution, 2020 - academic.oup.com
Recombination increases the local GC-content in genomic regions through GC-biased
gene conversion (gBGC). The recent discovery of a large genomic region with extreme GC-…