Amphipathic α-helices create the dimerization interface in the bZIP and bHLH classes of
DNA-binding proteins. These amphipathic helices have been shown to enter into a wide variety …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

… Baxevanis in his private capacity. No official support or endorsement by the National Institutes
of Health or the United States Department of Health and Human Services is intended or …

Pendred syndrome is a recessively inherited disorder with the hallmark features of congenital
deafness and thyroid goitre. By some estimates, the disorder may account for upwards of …

Praise for the third edition of Bioinformatics" This book is a gem to read and use in practice."—Briefings
in Bioinformatics" This volume has a distinctive, special value as it offers an …

Introduction An understanding of ctenophore biology is critical for reconstructing events that
occurred early in animal evolution. The phylogenetic relationship of ctenophores (comb …

The murine gene CHD1 (MmCHD1) was previously isolated in a search for proteins that
bound a DNA promoter element. The presence of chromo (chromatin organization modifier) …

DNA mismatch repair is important because of its role in maintaining genomic integrity and
its association with hereditary non-polyposis colon cancer (HNPCC). To identify new human …

The subkingdom Bilateria encompasses the overwhelming majority of animals, including all
but four early-branching phyla: Porifera, Ctenophora, Placozoa, and Cnidaria. On average, …

Background Hox genes were critical to many morphological innovations of bilaterian
animals. However, early Hox evolution remains obscure. Phylogenetic, developmental, and …