User profiles for A. C. Wacholder

Aaron Wacholder

School of Medicine, University of Pittsburgh
Verified email at pitt.edu
Cited by 510

Theoretical models of the influence of genomic architecture on the dynamics of speciation

SM Flaxman, AC Wacholder, JL Feder… - Molecular …, 2014 - Wiley Online Library
… (AC) Fitness values over time within one deme. Orange line: average resident fitness;
purple line: average immigrant fitness; cyan line: maximum possible fitness given the alleles that …

Genome-wide congealing and rapid transitions across the speciation continuum during speciation with gene flow

JL Feder, P Nosil, AC Wacholder, SP Egan… - Journal of …, 2014 - academic.oup.com
Our current understanding of speciation is often based on considering a relatively small number
of genes, sometimes in isolation of one another. Here, we describe a possible emergent …

[HTML][HTML] Finding and extending ancient simple sequence repeat-derived regions in the human genome

JA Shortt, RP Ruggiero, C Cox, AC Wacholder… - Mobile DNA, 2020 - Springer
Background Previously, 3% of the human genome has been annotated as simple sequence
repeats (SSRs), similar to the proportion annotated as protein coding. The origin of much of …

[HTML][HTML] Inference of transposable element ancestry

AC Wacholder, C Cox, TJ Meyer, RP Ruggiero… - PLoS …, 2014 - journals.plos.org
Most common methods for inferring transposable element (TE) evolutionary relationships
are based on dividing TEs into subfamilies using shared diagnostic nucleotides. Although …

PRDM9 and an Epidemic of Gene Conversion and Non-Homologous Recombination among Alu Elements in Ancestral Gorillas

AC Wacholder, DD Pollock - bioRxiv, 2017 - biorxiv.org
… of AC and A➔G substitutions that would result from GC-biased allelic gene conversion. The
100 bp flanking regions of depleted motifs show substantially elevated rates of AC and A➔…

[HTML][HTML] Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica

…, JT Schiller, DR Lowy, LJ van Doorn, S Wacholder… - PloS one, 2013 - journals.plos.org
Background Human papillomavirus (HPV) infection, particularly with type 16, causes a growing
fraction of oropharyngeal cancers, whose incidence is increasing, mainly in developed …

[PDF][PDF] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

…, Q Li, D Consonni, AC Pesatori, S Wacholder… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well …

Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study

…, AC Rodríguez, RD Burk, R Herrero, S Wacholder… - Bmj, 2009 - bmj.com
Objective To evaluate the cumulative incidence of cervical intraepithelial neoplasia II or
worse (grade II+) or cervical intraepithelial neoplasia grade III+ after short term persistence of …

Strong and Fluctuating Sequence Constraints Drive Alu_ Evolution

AC Wacholder, DD Pollock - bioRxiv, 2016 - biorxiv.org
… All replicative ancestors in the oldest component appear to have a C at this position, while
all younger ancestors have a G. Other sites, such as position 153 (Figure 3B) or position 70 (…

Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections

…, M Schiffman, R Herrero, S Wacholder… - Journal of the …, 2008 - academic.oup.com
AC Rodríguez was supported by an appointment to the Senior Fellowship Program at the
National Institutes of Health for analysis and manuscript preparation. The program is …