User profiles for A. C. Wacholder
Aaron WacholderSchool of Medicine, University of Pittsburgh Verified email at pitt.edu Cited by 510 |
Theoretical models of the influence of genomic architecture on the dynamics of speciation
SM Flaxman, AC Wacholder, JL Feder… - Molecular …, 2014 - Wiley Online Library
… (A–C) Fitness values over time within one deme. Orange line: average resident fitness;
purple line: average immigrant fitness; cyan line: maximum possible fitness given the alleles that …
purple line: average immigrant fitness; cyan line: maximum possible fitness given the alleles that …
Genome-wide congealing and rapid transitions across the speciation continuum during speciation with gene flow
Our current understanding of speciation is often based on considering a relatively small number
of genes, sometimes in isolation of one another. Here, we describe a possible emergent …
of genes, sometimes in isolation of one another. Here, we describe a possible emergent …
[HTML][HTML] Finding and extending ancient simple sequence repeat-derived regions in the human genome
Background Previously, 3% of the human genome has been annotated as simple sequence
repeats (SSRs), similar to the proportion annotated as protein coding. The origin of much of …
repeats (SSRs), similar to the proportion annotated as protein coding. The origin of much of …
[HTML][HTML] Inference of transposable element ancestry
AC Wacholder, C Cox, TJ Meyer, RP Ruggiero… - PLoS …, 2014 - journals.plos.org
Most common methods for inferring transposable element (TE) evolutionary relationships
are based on dividing TEs into subfamilies using shared diagnostic nucleotides. Although …
are based on dividing TEs into subfamilies using shared diagnostic nucleotides. Although …
PRDM9 and an Epidemic of Gene Conversion and Non-Homologous Recombination among Alu Elements in Ancestral Gorillas
AC Wacholder, DD Pollock - bioRxiv, 2017 - biorxiv.org
… of A➔C and A➔G substitutions that would result from GC-biased allelic gene conversion. The
100 bp flanking regions of depleted motifs show substantially elevated rates of A➔C and A➔…
100 bp flanking regions of depleted motifs show substantially elevated rates of A➔C and A➔…
[HTML][HTML] Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica
…, JT Schiller, DR Lowy, LJ van Doorn, S Wacholder… - PloS one, 2013 - journals.plos.org
Background Human papillomavirus (HPV) infection, particularly with type 16, causes a growing
fraction of oropharyngeal cancers, whose incidence is increasing, mainly in developed …
fraction of oropharyngeal cancers, whose incidence is increasing, mainly in developed …
[PDF][PDF] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
…, Q Li, D Consonni, AC Pesatori, S Wacholder… - The american journal of …, 2009 - cell.com
Three genetic loci for lung cancer risk have been identified by genome-wide association
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well …
studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well …
Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study
Objective To evaluate the cumulative incidence of cervical intraepithelial neoplasia II or
worse (grade II+) or cervical intraepithelial neoplasia grade III+ after short term persistence of …
worse (grade II+) or cervical intraepithelial neoplasia grade III+ after short term persistence of …
Strong and Fluctuating Sequence Constraints Drive Alu_ Evolution
AC Wacholder, DD Pollock - bioRxiv, 2016 - biorxiv.org
… All replicative ancestors in the oldest component appear to have a C at this position, while
all younger ancestors have a G. Other sites, such as position 153 (Figure 3B) or position 70 (…
all younger ancestors have a G. Other sites, such as position 153 (Figure 3B) or position 70 (…
Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections
…, M Schiffman, R Herrero, S Wacholder… - Journal of the …, 2008 - academic.oup.com
… AC Rodríguez was supported by an appointment to the Senior Fellowship Program at the
National Institutes of Health for analysis and manuscript preparation. The program is …
National Institutes of Health for analysis and manuscript preparation. The program is …