User profiles for A. B. Rosenberg
Alexander B RosenbergParse Biosciences Verified email at parsebiosciences.com Cited by 2426 |
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding
To facilitate scalable profiling of single cells, we developed split-pool ligation-based transcriptome
sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that labels the …
sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that labels the …
Spatial and cell type transcriptional landscape of human cerebellar development
The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint
required to integrate environmental cues with developing motor, cognitive and emotional skills …
required to integrate environmental cues with developing motor, cognitive and emotional skills …
[PDF][PDF] Learning the sequence determinants of alternative splicing from millions of random sequences
Most human transcripts are alternatively spliced, and many disease-causing mutations affect
RNA splicing. Toward better modeling the sequence determinants of alternative splicing, …
RNA splicing. Toward better modeling the sequence determinants of alternative splicing, …
Microbial single-cell RNA sequencing by split-pool barcoding
INTRODUCTION Bacteria heterogeneously activate gene expression programs in response
to environmental changes, stress, and other stimuli. Such behavior may serve as a bet-…
to environmental changes, stress, and other stimuli. Such behavior may serve as a bet-…
Deep learning of the regulatory grammar of yeast 5′ untranslated regions from 500,000 random sequences
Our ability to predict protein expression from DNA sequence alone remains poor, reflecting
our limited understanding of cis-regulatory grammar and hampering the design of …
our limited understanding of cis-regulatory grammar and hampering the design of …
[PDF][PDF] A deep neural network for predicting and engineering alternative polyadenylation
Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …
[PDF][PDF] A generative neural network for maximizing fitness and diversity of synthetic DNA and protein sequences
Engineering gene and protein sequences with defined functional properties is a major goal
of synthetic biology. Deep neural network models, together with gradient ascent-style …
of synthetic biology. Deep neural network models, together with gradient ascent-style …
[PDF][PDF] Redefining the etiologic landscape of cerebellar malformations
…, GM Mirzaa, JT Bennett, AB Rosenberg… - The American Journal of …, 2019 - cell.com
Cerebellar malformations are diverse congenital anomalies frequently associated with
developmental disability. Although genetic and prenatal non-genetic causes have been described…
developmental disability. Although genetic and prenatal non-genetic causes have been described…
[HTML][HTML] A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes
T Grancharova, KA Gerbin, AB Rosenberg, CM Roco… - Scientific Reports, 2021 - nature.com
We performed a comprehensive analysis of the transcriptional changes occurring during
human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using single cell …
human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using single cell …
MicroRNA-based single-gene circuits buffer protein synthesis rates against perturbations
TJ Strovas, AB Rosenberg, BE Kuypers… - ACS synthetic …, 2014 - ACS Publications
Achieving precise control of mammalian transgene expression has remained a long-standing,
and increasingly urgent, challenge in biomedical science. Despite much work, single-cell …
and increasingly urgent, challenge in biomedical science. Despite much work, single-cell …