User profiles for A. B. Bukhari
 | Amirali BukhariResearch Scientist, Alberta Health Services Verified email at ualberta.ca Cited by 1843 |
[HTML][HTML] IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples
F Varghese, AB Bukhari, R Malhotra, A De - PloS one, 2014 - journals.plos.org
In anatomic pathology, immunohistochemistry (IHC) serves as a diagnostic and prognostic
method for identification of disease markers in tissue samples that directly influences …
method for identification of disease markers in tissue samples that directly influences …
[HTML][HTML] Targeting the DNA damage response for cancer therapy by inhibiting the kinase Wee1
Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and …
exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and …
In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer
We report biodegradable plasmon resonant liposome gold nanoparticles (LiposAu NPs)
capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of …
capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of …
[HTML][HTML] Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis
AB Bukhari, CW Lewis, JJ Pearce… - The Journal of …, 2019 - Am Soc Clin Investig
We used the cancer-intrinsic property of oncogene-induced DNA damage as the base for a
conditional synthetic lethality approach. To target mechanisms important for cancer cell …
conditional synthetic lethality approach. To target mechanisms important for cancer cell …
[HTML][HTML] Quantitative immunohistochemical analysis reveals association between sodium iodide symporter and estrogen receptor expression in breast cancer
S Chatterjee, R Malhotra, F Varghese, AB Bukhari… - PloS one, 2013 - journals.plos.org
Background Human sodium iodide symporter (hNIS) gene over-expression is under active
consideration worldwide as an alternative target molecule for breast cancer (BC) diagnosis …
consideration worldwide as an alternative target molecule for breast cancer (BC) diagnosis …
Upregulation of Myt1 promotes acquired resistance of cancer cells to Wee1 inhibition
CW Lewis, AB Bukhari, EJ Xiao, WS Choi, JD Smith… - Cancer research, 2019 - AACR
… Lynne Postovit's breeding colony at the University of Alberta. Tumor volume was measured
every 4 days with a Vernier caliper, and volume was calculated as [length × (width) 2 ]/2. …
every 4 days with a Vernier caliper, and volume was calculated as [length × (width) 2 ]/2. …
Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model
…, KC Agopsowicz, RS Noyce, AB Bukhari… - Cancer Letters, 2023 - Elsevier
… The next day, mice were transported to the BSL2 facility at the University of Alberta and …
Flow cytometry was performed at the University of Alberta, Faculty of Medicine and Dentistry with …
Flow cytometry was performed at the University of Alberta, Faculty of Medicine and Dentistry with …
[HTML][HTML] EpCAM-mediated cellular plasticity promotes radiation resistance and metastasis in breast cancer
A substantial number of breast cancer (BC) patients undergoing radiation therapy (RT)
develop local recurrence over time. During RT therapy, cells can gradually acquire resistance …
develop local recurrence over time. During RT therapy, cells can gradually acquire resistance …
RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma
…, D Dieters‐Castator, AB Bukhari… - Molecular …, 2023 - Wiley Online Library
Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in
adults. The standard treatment achieves a median overall survival for GBM patients of only 15 …
adults. The standard treatment achieves a median overall survival for GBM patients of only 15 …
[HTML][HTML] α-Actinin-4 confers radioresistance coupled invasiveness in breast cancer cells through AKT pathway
Acquired radioresistance accompanied with increased metastatic potential is a major hurdle
in effective radiotherapy of breast cancers. However, the nature of their inter-dependence …
in effective radiotherapy of breast cancers. However, the nature of their inter-dependence …