Progress made in malaria control during the past decade has prompted increasing global
dialogue on malaria elimination and eradication. The product development pipeline for …

Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming
health, equity, and economic benefits. WHO and countries are setting ambitious goals for …

Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification
of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 …

In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine
nationwide in response to high rates of chloroquine-resistant falciparum malaria…

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown
to be important determinants of artemisinin resistance in Southeast Asia. This study …

Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the
artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum …

Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended
to prevent the parasite from invading and replicating within host cells. No blood-stage …

Residents of malaria-endemic areas sometimes spontaneously clear Plasmodium falciparum
infection without drug treatment, implying an important role for host factors such as …

Elucidation of the evolutionary history and interrelatedness of Plasmodium species that
infect humans has been hampered by a lack of genetic information for three human-infective …