User profiles for Ö. Carlborg

Örjan Carlborg

Professor in Computational Genomics, Uppsala University
Verified email at imbim.uu.se
Cited by 10823

Epistasis: too often neglected in complex trait studies?

Ö Carlborg, CS Haley - Nature Reviews Genetics, 2004 - nature.com
Interactions among loci or between genes and environmental factors make a substantial
contribution to variation in complex traits such as disease susceptibility. Nonetheless, many …

Evolutionary potential of hidden genetic variation

A Le Rouzic, Ö Carlborg - Trends in ecology & evolution, 2008 - cell.com
The ability of a population to respond to natural or artificial selection pressures is determined
by the genetic architecture of the selected trait. It is now widely acknowledged that a …

A century after Fisher: time for a new paradigm in quantitative genetics

RM Nelson, ME Pettersson, Ö Carlborg - Trends in Genetics, 2013 - cell.com
Quantitative genetics traces its roots back through more than a century of theory, largely
formed in the absence of directly observable genotype data, and has remained essentially …

[HTML][HTML] Whole-genome resequencing reveals loci under selection during chicken domestication

…, T Sharpe, S Ka, F Hallböök, F Besnier, Ö Carlborg… - Nature, 2010 - nature.com
Domestic animals are excellent models for genetic studies of phenotypic evolution 1 , 2 , 3 .
They have evolved genetic adaptations to a new environment, the farm, and have been …

The origin of the domestic pig: independent domestication and subsequent introgression

E Giuffra, JMH Kijas, V Amarger, Ö Carlborg, JT Jeon… - Genetics, 2000 - academic.oup.com
The domestic pig originates from the Eurasian wild boar (Sus scrofa). We have sequenced
mitochondrial DNA and nuclear genes from wild and domestic pigs from Asia and Europe. …

Strong signatures of selection in the domestic pig genome

…, D Schwochow, C Wang, Ö Carlborg… - Proceedings of the …, 2012 - National Acad Sciences
Domestication of wild boar (Sus scrofa) and subsequent selection have resulted in dramatic
phenotypic changes in domestic pigs for a number of traits, including behavior, body …

A paternally expressed QTL affecting skeletal and cardiac muscle mass in pigs maps to the IGF2 locus

JT Jeon, Ö Carlborg, A Törnsten, E Giuffra, V Amarger… - Nature …, 1999 - nature.com
Fig. 1 Test statistic curves obtained in QTL analyses of chromosome 2 in a Wild Boar/Large
White intercross. The graph plots the F ratio in a leastsquares analysis2, testing the …

Epistasis and the release of genetic variation during long-term selection

Ö Carlborg, L Jacobsson, P Åhgren, P Siegel… - Nature …, 2006 - nature.com
It is an enigma how long-term selection in model organisms and agricultural species can
lead to marked phenotypic changes without exhausting genetic variation for the selected trait. …

A global search reveals epistatic interaction between QTL for early growth in the chicken

Ö Carlborg, S Kerje, K Schütz, L Jacobsson… - Genome …, 2003 - genome.cshlp.org
We have identified quantitative trait loci (QTL) explaining a large proportion of the variation in
body weights at different ages and growth between chronological ages in an F 2 intercross …

The twofold difference in adult size between the red junglefowl and White Leghorn chickens is largely explained by a limited number of QTLs

S Kerje, Ö Carlborg, L Jacobsson, K Schütz… - Animal …, 2003 - Wiley Online Library
A large intercross between the domestic White Leghorn chicken and the wild ancestor, the
red junglefowl, has been used in a Quantitative Trait Loci (QTL) study of growth and egg …