Whole exome sequencing has proven to be a powerful tool for understanding the genetic
architecture of human disease. Here we apply it to more than 2,500 simplex families, each …

Exome sequencing of 343 families, each with a single child on the autism spectrum and at
least one unaffected sibling, reveal de novo small indels and point substitutions, which come …

CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9–…

The syndecan family of four transmembrane heparan sulfate proteoglycans binds a variety
of soluble and insoluble extracellular effectors. Syndecan extracellular domains (ectodomains…

CYTOTOXIC CD4 + Thl-cells induce cell death by triggering a Fas-dependent apoptotic
pathway 1–6 . Potential targets include activated B cells 3,7 , but it is not known whether the …

We present an open-source algorithm, Scalpel ( http://scalpel.sourceforge.net/ ), which combines
mapping and assembly for sensitive and specific discovery of insertions and deletions (…

Transgenic expression in the hypothalamus of syndecan-1, a cell surface heparan sulfate
proteoglycan (HSPG) and modulator of ligand-receptor encounters, produces mice with …

The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion,
migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a …

Nanovaccines have emerged as promising alternatives or complements to conventional
cancer treatments. Despite the progresses, specific co‐delivery of antigen and adjuvant to their …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to tumor …