Based on a course in the theory of statistics this text concentrates on what can be achieved
using the likelihood/Fisherian method of taking account of uncertainty when studying a …

Motivation: In microarray data studies most researchers are keenly aware of the potentially
high rate of false positives and the need to control it. One key statistical shift is the move away …

A key component of genetic architecture is the allelic spectrum influencing trait variability.
For autism spectrum disorder (herein termed autism), the nature of the allelic spectrum is …

Background Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete
or shared causative processes is much debated in psychiatry. We aimed to assess genetic …

Introduction Adjuvant breast cancer therapy significantly improves survival, but overtreatment
and undertreatment are major problems. Breast cancer expression profiling has so far …

Motivation: Analysing next-generation sequencing (NGS) data for copy number variations (CNVs)
detection is a relatively new and challenging field, with no accepted standard …

Perturbations of the p53 pathway are associated with more aggressive and therapeutically
refractory tumors. However, molecular assessment of p53 status, by using sequence analysis …

This is the second edition of a monograph on generalized linear models with random effects
that extends the classic work of McCullagh and Nelder. It has been thoroughly updated, with …

Histologic grading of breast cancer defines morphologic subtypes informative of metastatic
potential, although not without considerable interobserver disagreement and clinical …

Individualization of cancer management requires prognostic markers and therapy-predictive
markers. Prognostic markers assess risk of disease progression independent of therapy, …