Cryo-EM structure of the mature dengue virus at 3.5-Å resolution
Regulated by pH, membrane-anchored proteins E and M function during dengue virus
maturation and membrane fusion. Our atomic model of the whole virion from cryo–electron …
maturation and membrane fusion. Our atomic model of the whole virion from cryo–electron …
3.88 Å structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy
X Yu, L Jin, ZH Zhou - Nature, 2008 - nature.com
Cytoplasmic polyhedrosis virus (CPV) is unique within the Reoviridae family in having a
turreted single-layer capsid contained within polyhedrin inclusion bodies, yet being fully …
turreted single-layer capsid contained within polyhedrin inclusion bodies, yet being fully …
Cryo-EM structure of human heptameric Pannexin 1 channel
R Qu, L Dong, J Zhang, X Yu, L Wang, S Zhu - Cell Research, 2020 - nature.com
Dear Editor, Cellular communication is crucial during basic development and in the
maintenance of homeostasis in adult organisms, and such communication involves the connexin …
maintenance of homeostasis in adult organisms, and such communication involves the connexin …
[HTML][HTML] Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus
Z Li, J Pang, R Gao, Q Wang, M Zhang, X Yu - Nature Communications, 2023 - nature.com
The portal-scaffold complex is believed to nucleate the assembly of herpesvirus procapsids.
During capsid maturation, two events occur: scaffold expulsion and DNA incorporation. The …
During capsid maturation, two events occur: scaffold expulsion and DNA incorporation. The …
[HTML][HTML] Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
…, Y Jiang, H Jiang, G Xiao, L Zhang, X Yu… - Nature structural & …, 2021 - nature.com
The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to
ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a …
ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a …
[PDF][PDF] GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
…, H Zhang, K Harpsøe, H Li, Y Zhang, C You, X Yu… - Molecular cell, 2022 - cell.com
Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12
different G protein-coupled receptors (GPCRs) through selective coupling of G s , G i, or G q …
different G protein-coupled receptors (GPCRs) through selective coupling of G s , G i, or G q …
A complex structure of arrestin-2 bound to a G protein-coupled receptor
Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs),
which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to …
which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to …
Atomic structures of a bactericidal contractile nanotube in its pre-and postcontraction states
R-type pyocins are representatives of contractile ejection systems, a class of biological
nanomachines that includes, among others, the bacterial type VI secretion system (T6SS) and …
nanomachines that includes, among others, the bacterial type VI secretion system (T6SS) and …
Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150
INTRODUCTION Human cytomegalovirus (HCMV) is a leading cause of congenital defects
and a major contributor to life-threatening complications in immunocompromised individuals. …
and a major contributor to life-threatening complications in immunocompromised individuals. …
[HTML][HTML] 3.5 Å cryoEM structure of hepatitis B virus core assembled from full-length core protein
The capsid shell of infectious hepatitis B virus (HBV) is composed of 240 copies of a single
protein called HBV core antigen (HBc). An atomic model of a core assembled from truncated …
protein called HBV core antigen (HBc). An atomic model of a core assembled from truncated …