The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival.
However, the mechanism of KDM6B action remains poorly defined. We demonstrate that …

Diffuse axonal injury is thought to be the basis of the functional impairments stemming from
mild traumatic brain injury. To examine how axons are damaged by traumatic events, such …

2627 Background: Higher non-synonymous tumor mutation burden (TMB) in non-small cell
lung cancer (NSCLC) is associated with a higher likelihood of response to checkpoint …

Osimertinib, a third-generation EGFR tyrosine kinase inhibitor, is the preferred frontline
therapy for EGFR-mutant advanced NSCLC. However, despite its high initial response rates, …

Background Higher tumor mutation burden (TMB) in advanced non-small cell lung cancer (NSCLC)
is associated with superior outcomes with checkpoint inhibitor therapy. Tissue …

DISCUSSION: Ectopic ACTH syndrome is a rare disease with an incidence rate of 0.1 cases
per million per year. Our case report presents a 31-year-old female with Cushing’s …

The H3K27me2/me3 histone demethylase KDM6B is over-expressed in neuroblastoma and
essential to neuroblastoma cell survival. While the KDM6B inhibitor, GSK-J4, has shown …

Pulmonary emboli have varied clinical presentations and are largely determined by the size
and position of these emboli. Symptoms include no symptoms at all, dyspnea, cough, or …

DISCUSSION: IPM is a rare phenomenon that represents 1% of metastatic melanomas.
Patients with melanoma and distant metastases have a median survival of less than 1 year. …