The phenotypic effect of a gene is normally described by the mean-difference between
alternative genotypes. A gene may, however, also influence the phenotype by causing a …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we …

Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification, …

Parkinson disease (PD) is a progressive, neurodegenerative movement disorder with
symptoms reflecting various impairments and functional limitations, such as postural instability, …

We previously reported damage and elevated biogenesis in cardiac mitochondria of a type
1 diabetic mouse model and proposed that mitochondria are one of the major targets of …

Background: Recent population studies have suggested that children with multiple exposures
to anesthesia and surgery at an early age are at an increased risk of cognitive impairment. …

Intelligent transportation systems (ITS) are becoming a crucial component of our society,
whereas reliable and efficient vehicular communications consist of a key enabler of a well-…

Oral fast-dissolving drug delivery membranes (FDMs) for poorly water-soluble drugs were
prepared via electrospinning technology with ibuprofen as the model drug and …

Postural instability and falls are complex and disabling features of Parkinson’s disease (PD)
and respond poorly to anti-Parkinsonian medication. There is an imperative need to …

Diabetic cardiomyopathy is a common complication leading to heightened risk of heart failure
and death. In the present report, we performed proteomic analysis on total cardiac proteins …