Cancer cells characteristically consume glucose through Warburg metabolism 1 , a process
that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-…

Heart valves (HVs) are fluidic control components of the heart that ensure unidirectional blood
flow during the cardiac cycle. However, this description does not adequately describe the …

It has been speculated that heart valve interstitial cells (VICs) maintain valvular tissue
homeostasis through regulated extracellular matrix (primarily collagen) biosynthesis. VICs appear …

Objectives : Our objective in this study was to apply an elastic, biodegradable polyester
urethane urea (PEUU) cardiac patch onto subacute infarcts and to examine the resulting cardiac …

Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as …

BACKGROUND: Phenotypically, aortic valve interstitial cells are dynamic myofibroblasts,
appearing contractile and activated in times of development, disease, and remodeling. The …

Rationale: The lack of measurable single-cell contractility of human-induced pluripotent
stem cell–derived cardiac myocytes (hiPSC-CMs) currently limits the utility of hiPSC-CMs for …

Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …

… Schroer, W. David Merryman; Mechanobiology of myofibroblast adhesion in fibrotic
cardiac disease. J Cell Sci 15 May 2015; 128 (10): 1865–1875. doi: https://doi.org/10.1242/jcs.…

The aortic valve (AV) leaflet contains a heterogeneous interstitial cell population composed
predominantly of myofibroblasts, which contain both fibroblast and smooth muscle cell …