Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array

…, HP Lang, MK Baller, U Certa… - Proceedings of the …, 2002 - National Acad Sciences
We report a microarray of cantilevers to detect multiple unlabeled biomolecules simultaneously
at nanomolar concentrations within minutes. Ligand-receptor binding interactions such …

[HTML][HTML] Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster

SD Pletcher, SJ Macdonald, R Marguerie, U Certa… - Current Biology, 2002 - cell.com
Background: We characterized RNA transcript levels for the whole Drosophila genome
during normal aging. We compared age-dependent profiles from animals aged under full-nutrient …

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

…, M Prummer, CR Warren, R Jakob-Roetne, U Certa… - Nature cell …, 2015 - nature.com
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications
requires protocols that convert these cells into relevant adult cell types. Here, we report …

Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA

…, F Huber, A Bietsch, W Grange, U Certa… - Nature …, 2006 - nature.com
The availability of entire genome sequences has triggered the development of microarrays
for clinical diagnostics that measure the expression levels of specific genes. Methods that …

Roles of AUF1 isoforms, HuR and BRF1 in ARE‐dependent mRNA turnover studied by RNA interference

I Raineri, D Wegmueller, B Gross, U Certa… - Nucleic acids …, 2004 - academic.oup.com
HT1080 cells stably expressing green fluorescent protein (GFP) linked to a 3′ terminal AU‐rich
element (ARE) proved to be a convenient system to study the dynamics of mRNA …

The small interferon-induced transmembrane genes and proteins

F Siegrist, M Ebeling, U Certa - Journal of Interferon & Cytokine …, 2011 - liebertpub.com
Interferon-induced transmembrane (IFITM) genes are transcribed in most tissues and are
with the exception of IFITM5 interferon inducible. They are involved in early development, cell …

Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment

…, R Schmucki, H Biller, T Singer, U Certa - Genome …, 2011 - genome.cshlp.org
The long-tailed macaque, also referred to as cynomolgus monkey (Macaca fascicularis), is
one of the most important nonhuman primate animal models in basic and applied biomedical …

Hippocampal‐dependent spatial memory functions might be lateralized in rats: An approach combining gene expression profiling and reversible inactivation

…, T Ballard, J Lopez, R Galani, U Certa… - …, 2009 - Wiley Online Library
The hippocampus is involved in spatial memory processes, as established in a variety of
species such as birds and mammals including humans. In humans, some hippocampal‐…

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

…, M Seiler, M Neeb, J Mous, F Sinigaglia, U Certa - Nature …, 2000 - nature.com
Many pathological processes, including those causing allergies and autoimmune diseases,
are associated with the presence of specialized subsets of T helper cells at the site of …

Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells

E Padovan, L Terracciano, U Certa, B Jacobs… - Cancer research, 2002 - AACR
The immunobiology of tumor-infiltrating dendritic cells (DCs) can be strongly influenced by
the cytokine environment present in the malignant tissue. We have previously identified …