Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array
We report a microarray of cantilevers to detect multiple unlabeled biomolecules simultaneously
at nanomolar concentrations within minutes. Ligand-receptor binding interactions such …
at nanomolar concentrations within minutes. Ligand-receptor binding interactions such …
[HTML][HTML] Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster
SD Pletcher, SJ Macdonald, R Marguerie, U Certa… - Current Biology, 2002 - cell.com
Background: We characterized RNA transcript levels for the whole Drosophila genome
during normal aging. We compared age-dependent profiles from animals aged under full-nutrient …
during normal aging. We compared age-dependent profiles from animals aged under full-nutrient …
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications
requires protocols that convert these cells into relevant adult cell types. Here, we report …
requires protocols that convert these cells into relevant adult cell types. Here, we report …
Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA
The availability of entire genome sequences has triggered the development of microarrays
for clinical diagnostics that measure the expression levels of specific genes. Methods that …
for clinical diagnostics that measure the expression levels of specific genes. Methods that …
Roles of AUF1 isoforms, HuR and BRF1 in ARE‐dependent mRNA turnover studied by RNA interference
I Raineri, D Wegmueller, B Gross, U Certa… - Nucleic acids …, 2004 - academic.oup.com
HT1080 cells stably expressing green fluorescent protein (GFP) linked to a 3′ terminal AU‐rich
element (ARE) proved to be a convenient system to study the dynamics of mRNA …
element (ARE) proved to be a convenient system to study the dynamics of mRNA …
The small interferon-induced transmembrane genes and proteins
F Siegrist, M Ebeling, U Certa - Journal of Interferon & Cytokine …, 2011 - liebertpub.com
Interferon-induced transmembrane (IFITM) genes are transcribed in most tissues and are
with the exception of IFITM5 interferon inducible. They are involved in early development, cell …
with the exception of IFITM5 interferon inducible. They are involved in early development, cell …
Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment
…, R Schmucki, H Biller, T Singer, U Certa - Genome …, 2011 - genome.cshlp.org
The long-tailed macaque, also referred to as cynomolgus monkey (Macaca fascicularis), is
one of the most important nonhuman primate animal models in basic and applied biomedical …
one of the most important nonhuman primate animal models in basic and applied biomedical …
Hippocampal‐dependent spatial memory functions might be lateralized in rats: An approach combining gene expression profiling and reversible inactivation
…, T Ballard, J Lopez, R Galani, U Certa… - …, 2009 - Wiley Online Library
The hippocampus is involved in spatial memory processes, as established in a variety of
species such as birds and mammals including humans. In humans, some hippocampal‐…
species such as birds and mammals including humans. In humans, some hippocampal‐…
Transcript imaging of the development of human T helper cells using oligonucleotide arrays
…, M Seiler, M Neeb, J Mous, F Sinigaglia, U Certa - Nature …, 2000 - nature.com
Many pathological processes, including those causing allergies and autoimmune diseases,
are associated with the presence of specialized subsets of T helper cells at the site of …
are associated with the presence of specialized subsets of T helper cells at the site of …
Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells
E Padovan, L Terracciano, U Certa, B Jacobs… - Cancer research, 2002 - AACR
The immunobiology of tumor-infiltrating dendritic cells (DCs) can be strongly influenced by
the cytokine environment present in the malignant tissue. We have previously identified …
the cytokine environment present in the malignant tissue. We have previously identified …