Gene drive systems that enable super-Mendelian inheritance of a transgene have the
potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 …

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …

Anopheline mosquito species are obligatory vectors for human malaria, an infectious disease
that affects hundreds of millions of people living in tropical and subtropical countries. The …

Mosquitoes containing gene drive systems are being developed as complementary tools to
prevent transmission of malaria and other mosquito-borne diseases. As with any new tool, …

Background The mosquito, Anopheles gambiae, is the primary vector of human malaria, a
disease responsible for millions of deaths each year. To improve strategies for controlling …

It is estimated that every year malaria infects ∼300 million people and accounts for the
death of 2 million individuals. The Plasmodium parasites that cause malaria in humans are …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

Transgenesis is an essential tool to investigate gene function and to introduce desired
characters in laboratory organisms. Setting-up transgenesis in non-model organisms is …

Malaria kills millions of people every year, and new control measures are urgently needed.
The recent demonstration that (effector) genes can be introduced into the mosquito germ line …