Temporal genomic data hold great potential for studying evolutionary processes such as
speciation. However, sampling across speciation events would, in many cases, require …

Many endangered species have experienced severe population declines within the last
centuries [1, 2]. However, despite concerns about negative fitness effects resulting from …

Increasing habitat fragmentation leads to wild populations becoming small, isolated, and
threatened by inbreeding depression. However, small populations may be able to purge …

The high‐throughput capacities of the Illumina sequencing platforms and the possibility to
label samples individually have encouraged wide use of sample multiplexing. However, this …

Small populations are often exposed to high inbreeding and mutational load that can increase
the risk of extinction. The Sumatran rhinoceros was widespread in Southeast Asia, but is …

The kākāpō is a flightless parrot endemic to New Zealand. Once common in the archipelago,
only 201 individuals remain today, most of them descending from an isolated island …

Only five species of the once-diverse Rhinocerotidae remain, making the reconstruction of
their evolutionary history a challenge to biologists since Darwin. We sequenced genomes …

Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct
organisms. However, the identification of species-specific fixed genetic variants requires the …

… Tom van der Valk … 46.van der Valk T, de Manuel M, Marques-Bonet T, Guschanski K.
Estimates of genetic load in small populations suggest extensive purging of … Tom van der Valk …

Abstract Analysis of microbial data from archaeological samples is a growing field with great
potential for understanding ancient environments, lifestyles, and diseases. However, high …