PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis
ED Parvanov, H Tian, T Billings, RL Saxl… - Molecular biology of …, 2017 - Am Soc Cell Biol
In mammals, meiotic recombination occurs at 1- to 2-kb genomic regions termed hotspots,
whose positions and activities are determined by PRDM9, a DNA-binding histone …
whose positions and activities are determined by PRDM9, a DNA-binding histone …
[HTML][HTML] DNA binding specificities of the long zinc-finger recombination protein PRDM9
T Billings, ED Parvanov, CL Baker, M Walker, K Paigen… - Genome biology, 2013 - Springer
Background Meiotic recombination ensures proper segregation of homologous chromosomes
and creates genetic variation. In many organisms, recombination occurs at limited sites, …
and creates genetic variation. In many organisms, recombination occurs at limited sites, …
[HTML][HTML] Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage
M Walker, T Billings, CL Baker, N Powers, H Tian… - Epigenetics & …, 2015 - Springer
Background Genetic recombination plays an important role in evolution, facilitating the
creation of new, favorable combinations of alleles and the removal of deleterious mutations by …
creation of new, favorable combinations of alleles and the removal of deleterious mutations by …
Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome
DP Liu, C Schmidt, T Billings, MT Davisson - Biotechniques, 2003 - Future Science
The Ts65Dn mouse is a segmentally trisomic model for Down syndrome. Until now, Ts65Dn
mice have been identified by the laborious methods of either chromosomal analysis of …
mice have been identified by the laborious methods of either chromosomal analysis of …
On the dependent recognition of some long zinc finger proteins
Z Zuo, T Billings, M Walker, PM Petkov… - Nucleic acids …, 2023 - academic.oup.com
The human genome contains about 800 C2H2 zinc finger proteins (ZFPs), and most of them
are composed of long arrays of zinc fingers. Standard ZFP recognition model asserts longer …
are composed of long arrays of zinc fingers. Standard ZFP recognition model asserts longer …
[HTML][HTML] CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse
H Tian, T Billings, PM Petkov - PLoS genetics, 2018 - journals.plos.org
In most mammals, including mice and humans, meiotic recombination is determined by the
meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences …
meiosis specific histone methytransferase PRDM9, which binds to specific DNA sequences …
[HTML][HTML] Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping
T Billings, EE Sargent, JP Szatkiewicz, N Leahy… - PloS one, 2010 - journals.plos.org
The success of high resolution genetic mapping of disease predisposition and quantitative
trait loci in humans and experimental animals depends on the positions of key crossover …
trait loci in humans and experimental animals depends on the positions of key crossover …
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8
H Tian, T Billings, PM Petkov - Molecular biology of the cell, 2021 - Am Soc Cell Biol
Meiotic recombination in most mammals requires recombination hotspot activation through
the action of the histone 3 Lys-4 and Lys-36 methyltransferase PRDM9 to ensure successful …
the action of the histone 3 Lys-4 and Lys-36 methyltransferase PRDM9 to ensure successful …
Caterwauling Cataians: the genealogy of a gloss
T Billings - Shakespeare quarterly, 2003 - academic.oup.com
… That critique appears in ^JStff, "Cataians WTf i«3i III Cathay l'l'J.i'*)II — W Iftl fp m R- '<& fflA'
05 ft g," 5B in M, K *J II »l [Timothy Billings, "Caterwauling Catalans and the Catachresis of …
05 ft g," 5B in M, K *J II »l [Timothy Billings, "Caterwauling Catalans and the Catachresis of …
Brief vs. extended buprenorphine detoxification in a community treatment program: engagement and short-term outcomes
…, DA Highfield, KE O'Grady, T Billings… - The American journal …, 2009 - Taylor & Francis
Background: Despite evidence supporting the efficacy of buprenorphine relative to established
detoxification agents such as clonidine, little research has examined: 1) how best to …
detoxification agents such as clonidine, little research has examined: 1) how best to …