Key points Haem oxygenase 1 (Hmox1) is a cytoprotective enzyme with anti‐inflammatory
and anti‐oxidant properties that is induced in response to multiple noxious environmental …

Many drugs targeting the DNA damage response are being developed as anticancer therapies,
either as single agents or in combination with ionizing radiation (IR) or other cytotoxic …

Inorganic arsenic (iAs) is a naturally occurring metalloid present in drinking water and
polluted air exposing millions of people globally. Epidemiological studies have linked iAs …

Many drugs targeting the DNA damage response are being developed as anti-cancer therapies,
either as single agents or in combination with ionising radiation or other cytotoxic agents…

Hmox1 protein holds great promise as a biomarker of organismal health as it is highly expressed
in stressed or damaged cells. However, documenting Hmox1 expression patterns has …

… The homogenate was centrifuged for 80 minutes at 100,000g (30,000 rpm in an F50L rotor)
… We thank Julia Carr, Lulu Acosta, and Tanya Frangova for assistance with animal work. We …

… , 20 mM Tris-HCL, pH 7.4; 9 ml buffer/g liver) and centrifuged at 2000 rpm (Sorvall RTH-250,
10 … Kenneth MacLeod, and Tanya Frangova with animal work is gratefully acknowledged. …

Introduction: L-Arginine (Arg) is a semi-essential amino acid. Constitutive and inducible
nitric oxide synthase (NOS) isoforms convert Arg to nitric oxide (NO), a potent vaso- and …

Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic
biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and …

… G. MCF7-AREc32 cells were incubated with 3-NFA (50 μM) for 24 h and GSH/GSSG ratio …
We also thank Tanya Frangova, Febe Ferro and Cheryl Wood for technical assistance. …