Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid
progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in …

Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in
melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. We …

Radiation therapy is a highly effective local treatment for cancer. However, sporadic events
of tumor regression in unirradiated fields, known as abscopal effect, have been observed for …

Despite advances in treatment, cancer remains the 2nd most common cause of death in the
United States. Poor cure rates may result from the ability of cancer to recur and spread after …

Invariant NKT (iNKT) cells recognize glycolipid Ags, such as the marine sponge-derived
glycosphingolipid α-galactosylceramide (αGalCer) presented by the CD1d protein. In vivo …

Background Merkel cell carcinoma is among the most aggressive and lethal of primary skin
cancers, with a high rate of distant metastasis. Anti-programmed death receptor 1 (anti-PD-1) …

Obesity triggers a low-grade systemic inflammation, which plays an important role in the
development of obesity-associated metabolic diseases. In searching for links between lipid …

While STING-activating agents have shown limited efficacy in early-phase clinical trials,
multiple lines of evidence suggest the importance of tumor cell-intrinsic STING function in …

Radiotherapy has long been the mainstay of treatment for patients with head and neck cancer
and has traditionally involved a stage-dependent strategy whereby all patients with the …

Radiation therapy (RT) is a cornerstone in oncologic management and is employed in various
curative and palliative scenarios for local-regional control. RT is thought to locally control …