There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental, …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …

Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or confounded. …

Background: While clinical outcomes from colorectal cancer (CRC) are influenced by stage
at diagnosis and treatment, mounting evidence suggests that an enhanced lymphocytic …

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and
common genetic variants that contribute to familial risk. Here we report the results of a two-stage …

Background Previous genome-wide association studies (GWAS) have identified 42 loci (P <
5 × 10 −8 ) associated with risk of colorectal cancer (CRC). Expanded consortium efforts …

… Stephanie L Schmit: Critical revision of the manuscript for important intellectual content.
Christopher K Edlund: Critical revision of the manuscript for important intellectual content. …

Background & Aims Genome-wide association studies (GWASs) have associated approximately
50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci were initially …

Quantifying the genetic correlation between cancers can provide important insights into the
mechanisms driving cancer etiology. Using genome-wide association study summary …