For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …

The Arabidopsis accelerated cell death 6-1 (acd6-1) mutant shows constitutive defense, cell
death, and extreme dwarf phenotypes. In a screen for acd6-1 suppressors, we identified a …

Mitochondria carry their own circular genome and disruption of the mitochondrial genome is
associated with various aging-related diseases. Unlike the nuclear genome, mitochondrial …

Oocyte maturation is a coordinated process that is tightly linked to reproductive potential. A
better understanding of gene regulation during human oocyte maturation will not only answer …

During mammalian embryogenesis, changes in morphology and gene expression are concurrent
with epigenomic reprogramming. Using human embryonic stem cells representing the …

Assisted reproductive technologies are known to alter the developmental environment of
gametes and early embryos during the most dynamic period of establishing the epigenome. …

Mitochondrial diseases are a heterogeneous group of disorders that can be caused by
mutations in the nuclear or mitochondrial genome. Mitochondrial DNA (mtDNA) variants may …

Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion
prior to use as cell-based therapies in immunological and tissue repair applications. Aging …

The small phenolic compound salicylic acid (SA) plays a critical role in plant defense against
broad-spectrum of pathogens. The phosphate transporter gene PHT4;1 was previously …

Methods We used data on 45,665 participants from the UK Biobank who were enrolled in
2010 with available whole genome sequencing (WGS) data. 6 Study participants provided …