BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal cancer.
Identifying the genetic loci associated with colorectal tumor formation could elucidate the …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172
individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate…

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

Purpose : More than 1 million prostate biopsies are performed annually among Medicare
beneficiaries. We determined the risk of serious complications requiring hospitalization. We …

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …