[HTML][HTML] Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
A new and highly pathogenic coronavirus (severe acute respiratory syndrome coronavirus-2,
SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China, starting from …
SARS-CoV-2) caused an outbreak in Wuhan city, Hubei province, China, starting from …
DWARF14 is a non-canonical hormone receptor for strigolactone
…, D Miao, Z Sun, J Yan, Y Sun, L Wang, J Chu, S Fan… - Nature, 2016 - nature.com
Classical hormone receptors reversibly and non-covalently bind active hormone molecules,
which are generated by biosynthetic enzymes, to trigger signal transduction. The α/β …
which are generated by biosynthetic enzymes, to trigger signal transduction. The α/β …
The crystal structure of Cpf1 in complex with CRISPR RNA
…, B Zhang, D Yang, C Ma, S Wang, D Wu, Y Ma, S Fan… - Nature, 2016 - nature.com
The CRISPR–Cas systems, as exemplified by CRISPR–Cas9, are RNA-guided adaptive
immune systems used by bacteria and archaea to defend against viral infection 1 , 2 , 3 , 4 , 5 , …
immune systems used by bacteria and archaea to defend against viral infection 1 , 2 , 3 , 4 , 5 , …
Molecular basis of ligand recognition and transport by glucose transporters
The major facilitator superfamily glucose transporters, exemplified by human GLUT1–4, have
been central to the study of solute transport. Using lipidic cubic phase crystallization and …
been central to the study of solute transport. Using lipidic cubic phase crystallization and …
Structural and biochemical basis for induced self-propagation of NLRC4
Responding to stimuli, nucleotide-binding domain and leucine-rich repeat–containing
proteins (NLRs) oligomerize into multiprotein complexes, termed inflammasomes, mediating …
proteins (NLRs) oligomerize into multiprotein complexes, termed inflammasomes, mediating …
Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor
J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - BioRxiv, 2020 - biorxiv.org
A novel and highly pathogenic coronavirus (2019-nCoV) has caused an outbreak in Wuhan
city, Hubei province of China since December 2019, and soon spread nationwide and …
city, Hubei province of China since December 2019, and soon spread nationwide and …
[HTML][HTML] Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins
…, Y Yang, X Wang, Q Wang, QX Zhang, S Fan… - Nature …, 2016 - nature.com
As a large family of RNA-binding proteins, pentatricopeptide repeat (PPR) proteins mediate
multiple aspects of RNA metabolism in eukaryotes. Binding to their target single-stranded …
multiple aspects of RNA metabolism in eukaryotes. Binding to their target single-stranded …
[HTML][HTML] Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction
Dear Editor, The global fight against the COVID-19 pandemic is still in great uncertainty due
to the emergence of SARS-CoV-2 variants, especially the variants of concern (VOCs) with …
to the emergence of SARS-CoV-2 variants, especially the variants of concern (VOCs) with …
[HTML][HTML] Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption
COVID-19 patients transmitted SARS-CoV-2 to minks in the Netherlands in April 2020.
Subsequently, the mink-associated virus (miSARS-CoV-2) spilled back over into humans. Genetic …
Subsequently, the mink-associated virus (miSARS-CoV-2) spilled back over into humans. Genetic …
Structural basis of ubiquitin modification by the Legionella effector SdeA
Protein ubiquitination is a multifaceted post-translational modification that controls almost
every process in eukaryotic cells. Recently, the Legionella effector SdeA was reported to …
every process in eukaryotic cells. Recently, the Legionella effector SdeA was reported to …