Bordetella respiratory infections are common in people (B. pertussis) and in animals (B.
bronchiseptica). During the last two decades, much has been learned about the virulence …

Many bacterial pathogens use the type III secretion system to inject "effector" proteins into
host cells. Here, we report the identification of a 24 member effector protein family found in …

We show that the secreted antigen, IbpA, of the respiratory pathogen Histophilus somni
induces cytotoxicity in mammalian cells via its Fic domains. Fic domains are defined by a core …

Adherence to ciliated respiratory epithelial cells is considered a critical early step in Bordetella
pathogenesis. ForBordetella pertussis, the etiologic agent of whooping cough, several …

… Lastly, challenge experiments suggest that the presence of fimbriae is important to elicit
an immune response that is protective against superinfection (Mattoo et al., manuscript in …

Lafora disease (LD) is a progressive myoclonic epilepsy resulting in severe neurodegeneration
followed by death. A hallmark of LD is the accumulation of insoluble polyglucosans …

Bordetella species utilize the BvgAS (Bordetella virulence gene) two-component signal
transduction system to sense the environment and regulate gene expression among at least …

The maintenance of endoplasmic reticulum (ER) homeostasis is a critical aspect of determining
cell fate and requires a properly functioning unfolded protein response (UPR). We have …

The Fic family of adenylyltransferases, defined by a core HPFx(D/E)GN(G/K)R motif, consists
of over 2,700 proteins found in organisms from bacteria to humans. The immunoglobulin-…

The BvgAS virulence control system regulates the expression of type III secretion genes in
Bordetella subspecies that infect humans and other mammals. We have identified five open …