Several interconnected human, animal and environmental habitats can contribute to the
emergence, evolution and spread of antibiotic resistance, and the health of these contiguous …

Multidrug efflux pumps constitute a group of transporters that are ubiquitously found in any
organism. In addition to other functions with relevance for the cell physiology, efflux pumps …

The analysis of trade-offs, as collateral sensitivity, associated with the acquisition of
antibiotic resistance, is mainly based on the use of model strains. However, the possibility of …

Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all
microorganisms. With few exceptions, they are chromosomally encoded and present a conserved …

Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different levels.
Some efflux pumps are constitutively expressed at low levels and contribute to intrinsic …

Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

Antibiotic resistance is currently one of the most important public health problems. The golden
age of antibiotic discovery ended decades ago, and new approaches are urgently needed…

The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants
(ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic …

Antibiotic resistance is a problem for human health, and consequently, its study had been
traditionally focused toward its impact for the success of treating human infections in individual …

… Author links open overlay panel Pablo Laborda , Fernando Sanz-García , Sara Hernando-Amado
, José Luis Martínez … Hernando-Amado, TM Coque, F. Baquero, JL Martinez …