10.7554/eLife.31481.001 Histone tails harbor a plethora of post-translational modifications
that direct the function of chromatin regulators, which recognize them through effector …

The organization of genomic DNA into defined nucleosomes has long been viewed as a
hallmark of eukaryotes. This paradigm has been challenged by the identification of "minimalist" …

Eukaryotes and many archaea package their DNA with histones. While the four eukaryotic
histones wrap ~147 DNA base pairs into nucleosomes, archaeal histones form ‘nucleosome-…

The biochemical and biophysical investigation of proteins, nucleic acids, and the assemblies
that they form yields essential information to understand complex systems. Analytical …

Eukaryotes tune the transcriptional activity of their genome by altering the nucleosome core
particle through multiple chemical processes. In particular, replacement of the canonical …

Poly(ADP-ribose) Polymerase 2 (PARP2) is one of three DNA-dependent PARPs involved
in the detection of DNA damage. Upon binding to DNA double-strand breaks, PARP2 uses …

The three domains of life employ various strategies to organize their genomes. Archaea utilize
features similar to those found in both eukaryotic and bacterial chromatin to organize their …

PARP1 contributes to genome architecture and DNA damage repair through its dynamic
association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and …

Small-angle X-ray scattering (SAXS) has become an increasingly popular technique for
characterizing the solution ensemble of flexible biomolecules. However, data resulting from …

The fundamental unit of eukaryotic chromatin is the nucleosome core particle, a protein/DNA
complex that binds ∼147 base pairs of DNA to a histone octamer. These histones—H3, H4, …