Within the first three weeks of human immunodeficiency virus (HIV) infection, virus
replication peaks in peripheral blood. Despite the critical, causal role of virus replication in …

Very little is currently known about the major histocompatibility complex (MHC) region of
cynomolgus macaques (Macaca fascicularis; Mafa) from Chinese breeding centers. We …

Pig-tailed macaques (Macaca nemestrina, Mane) are important models for human
immunodeficiency virus (HIV) studies. Their infectability with minimally modified HIV makes them a …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Hundreds of thousands of genetic variants have been reported to cause severe monogenic
diseases, but the probability that a variant carrier develops the disease (termed penetrance) …

Squamous cell carcinoma has been reported in a variety of bird species, most commonly
psittacine and gallinaceous birds. The long-term prognosis in nongallinaceous birds is …

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS)
susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations …

Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …

Fenestrations are pores within the liver sinusoidal endothelial cells (LSECs) that line the
sinusoids of the highly vascularized liver. Fenestrations facilitate the transfer of substrates …

Niemann-Pick type C (NPC) disease is primarily caused by mutations in the NPC1 gene
and is characterized by the accumulation of unesterified cholesterol and lipids in the late …