Type I interferons (IFNs) are critical mediators of antiviral defense, but their elicitation by
bacterial pathogens can be detrimental to hosts. Many intracellular bacterial pathogens, …

Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill-defined. …

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells 1 ,
2 , 3 – 4 . The detection of pathogen-derived nucleic acids is a central strategy by which the …

Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal
forms of human malaria, is exposed to radically different environments and stress factors …

Mitochondrial dysfunction is a key driver of inflammatory responses in human disease.
However, it remains unclear whether alterations in mitochondria-innate immune cross-talk …

The Parkinson’s disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has
been studied extensively in the brain. However, several studies have established that …

Although macrophages are armed with potent antibacterial functions, Mycobacterium
tuberculosis (Mtb) replicates inside these innate immune cells. Determinants of macrophage …

Despite major strides in personalized genomics, it remains poorly understood why
neurodegenerative diseases occur in only a fraction of individuals with a genetic predisposition and …

Mycobacterium tuberculosis (Mtb) causes one of the deadliest infectious diseases
worldwide. Upon infection, Mtb is phagocytosed by macrophages and uses its virulence-associated …

Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate
immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic …