GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin
(PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn –/– …

Delivery of biotherapeutics across the blood–brain barrier (BBB) is a challenge. Many
approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain …

Background Genetic mutations underlying familial Alzheimer’s disease (AD) were identified
decades ago, but the field is still in search of transformative therapies for patients. While …

Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of
neuronal degeneration and axon growth. Therefore, there is a considerable interest in …

Microglial dysfunction is believed to play a pathogenic role in Alzheimer’s disease (AD).
Here, we characterize the amyloid-β related pathology and microglial responses in an …

The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is
activated in response to multiple sources of cellular stress. Although acute activation of this …

Background Heterozygous loss of function (LOF) mutations in GRN cause frontotemporal
dementia (FTD), a neurodegenerative disorder associated with lysosomal dysfunction, TDP‐43 …

(Cell 184, 4651–4668. e1–e25; September 2, 2021) In the originally published version of this
article, we reported tissue and fluid concentrations of PTV: PGRN and Fc: PGRN following …

… Miss Chau has received personal compensation for serving as an employee of Denali
Therapeutics. Miss Chau has stock in Denali Therapeutics. Timothy Earr has received personal …

… Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Sonnet S Davis,
Ray Lieh Yoon Low, Chi-Lu Chiu, Meng Fang, Fen Huang, Akhil Bhalla, Ceyda Llapashtica …