User profiles for Rohit Satija

Rohit Satija

Genentech
Verified email at gene.com
Cited by 354

Generalized Langevin equation as a model for barrier crossing dynamics in biomolecular folding

R Satija, DE Makarov - The Journal of Physical Chemistry B, 2019 - ACS Publications
Conformational memory in single-molecule dynamics has attracted recent attention and, in
particular, has been invoked as a possible explanation of some of the intriguing properties of …

Design of a toolbox of RNA thermometers

S Sen, D Apurva, R Satija, D Siegal… - ACS synthetic …, 2017 - ACS Publications
Biomolecular temperature sensors can be used for efficient control of large-volume bioreactors,
for spatiotemporal imaging and control of gene expression, and to engineer robustness …

[HTML][HTML] Transition path times reveal memory effects and anomalous diffusion in the dynamics of protein folding

R Satija, A Das, DE Makarov - The Journal of chemical physics, 2017 - pubs.aip.org
Recent single-molecule experiments probed transition paths of biomolecular folding and, in
particular, measured the time biomolecules spend while crossing their free energy barriers. …

Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes

R Satija, AM Berezhkovskii… - Proceedings of the …, 2020 - National Acad Sciences
Recent single-molecule experiments have observed transition paths, ie, brief events where
molecules (particularly biomolecules) are caught in the act of surmounting activation barriers. …

Transition path times in non-Markovian activated rate processes

E Medina, R Satija, DE Makarov - The Journal of Physical …, 2018 - ACS Publications
Transition paths are brief excursions taken by molecules when they cross barriers separating
stable molecular conformations. When observed in single-molecule experiments, they offer …

Protein turnover dynamics suggest a diffusion-to-capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins

JVK Hibbard, N Vazquez, R Satija… - Molecular biology of …, 2021 - Am Soc Cell Biol
Intraflagellar transport (IFT) is essential for construction and maintenance of cilia. IFT proteins
concentrate at the basal body where they are thought to assemble into trains and bind …

[HTML][HTML] Theoretical and computational validation of the Kuhn barrier friction mechanism in unfolded proteins

SM Avdoshenko, A Das, R Satija, GA Papoian… - Scientific Reports, 2017 - nature.com
A long time ago, Kuhn predicted that long polymers should approach a limit where their global
motion is controlled by solvent friction alone, with ruggedness of their energy landscapes …

Transition path dynamics of a dielectric particle in a bistable optical trap

N Zijlstra, D Nettels, R Satija, DE Makarov, B Schuler - Physical review letters, 2020 - APS
Many processes in chemistry, physics, and biology involve rare events in which the system
escapes from a metastable state by surmounting an activation barrier. Examples range from …

Kinetics of loop closure in disordered proteins: Theory vs simulations vs experiments

R Satija, A Das, S Mühle, J Enderlein… - The Journal of …, 2020 - ACS Publications
We study intrachain dynamics of intrinsically disordered proteins, as manifested by the time
scales of loop formation, using atomistic simulations, experiment-parametrized coarse-…

[BOOK][B] Understanding structural transitions and dynamics in biomolecules at a single molecule level

R Satija - 2020 - search.proquest.com
Rohit Satija 2020 … The Dissertation Committee for Rohit Satija Certifies that this is the approved
… I would also like to thank my very supportive family Bhumika, Lajvanti, and Yograj Satija, …