User profiles for Renwick C.J. Dobson

Renwick CJ Dobson

Professor of Chemical Biology, School of Biological Sciences, University of Canterbury
Verified email at canterbury.ac.nz
Cited by 19657

[HTML][HTML] The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

…, EC Hatchell, IJ Majewski, T Okamoto, RCJ Dobson… - Immunity, 2013 - cell.com
Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein
complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To …

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

…, C Pierotti, JM Garnier, RCJ Dobson… - Proceedings of the …, 2014 - National Acad Sciences
Necroptosis is considered to be complementary to the classical caspase-dependent programmed
cell death pathway, apoptosis. The pseudokinase Mixed Lineage Kinase Domain-Like …

[HTML][HTML] A three-ring circus: metabolism of the three proteogenic aromatic amino acids and their role in the health of plants and animals

A Parthasarathy, PJ Cross, RCJ Dobson… - Frontiers in molecular …, 2018 - frontiersin.org
Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Fermentation of plant‐based dairy alternatives by lactic acid bacteria

AR Harper, RCJ Dobson, VK Morris… - Microbial …, 2022 - Wiley Online Library
Ethical, environmental and health concerns around dairy products are driving a fast‐growing
industry for plant‐based dairy alternatives, but undesirable flavours and textures in …

[PDF][PDF] Bovine β-lactoglobulin is dimeric under imitative physiological conditions: dissociation equilibrium and rate constants over the pH range of 2.5–7.5

…, GE Norris, TS Loo, MAK Williams, RCJ Dobson… - Biophysical journal, 2012 - cell.com
The oligomerization of β-lactoglobulin (βLg) has been studied extensively, but with somewhat
contradictory results. Using analytical ultracentrifugation in both sedimentation equilibrium …

[HTML][HTML] Potential for bacteriophage endolysins to supplement or replace antibiotics in food production and clinical care

MJ Love, D Bhandari, RCJ Dobson, C Billington - Antibiotics, 2018 - mdpi.com
There is growing concern about the emergence of bacterial strains showing resistance to all
classes of antibiotics commonly used in human medicine. Despite the broad range of …

Structural and functional analysis of the GABARAP interaction motif (GIM)

…, F Löhr, S Wakatsuki, V Dötsch, I Dikic, RCJ Dobson… - EMBO …, 2017 - embopress.org
Through the canonical LC3 interaction motif (LIR), [W/F/Y]‐X 1 ‐X 2 ‐[I/L/V], protein complexes
are recruited to autophagosomes to perform their functions as either autophagy adaptors …

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

…, PE Czabotar, RCJ Dobson… - Proceedings of the …, 2015 - National Acad Sciences
Structural maintenance of chromosomes flexible hinge domain containing 1 (Smchd1) is an
epigenetic repressor with described roles in X inactivation and genomic imprinting, but …

[HTML][HTML] The quest for novel antimicrobial compounds: emerging trends in research, development, and technologies

PK Mantravadi, KA Kalesh, RCJ Dobson, AO Hudson… - Antibiotics, 2019 - mdpi.com
Pathogenic antibiotic resistant bacteria pose one of the most important health challenges of
the 21st century. The overuse and abuse of antibiotics coupled with the natural evolutionary …

[PDF][PDF] Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism

…, K Tabata, E Morita, M Kawasaki, R Kato, RCJ Dobson… - Structure, 2014 - cell.com
Autophagy is a bulk degradation pathway that removes cytosolic materials to maintain cellular
homeostasis. The autophagy-related gene 13 (Atg13) and microtubule associate protein 1 …