Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes,
but type 2 diabetes in particular is highly heterogeneous. A refined classification could …

Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …

Phosphoryl transfer plays key roles in signaling, energy transduction, protein synthesis, and
maintaining the integrity of the genetic material. On the surface, it would appear to be a …

Using data from a genome-wide association study of 907 individuals with childhood acute
lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling …

Type 2 diabetes has been reproducibly clustered into five subtypes with different disease
progression and risk of complications; however, etiological differences are unknown. We used …

Type 2 diabetes (T2D) is defined by a single metabolite, glucose, but is increasingly
recognized as a highly heterogeneous disease, including individuals with varying clinical …

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states.
Previous genetic studies have largely focused on insulin resistance in the fasting state, …

Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy
complications and adverse perinatal outcomes. GDM often reoccurs and is associated with …

Maize and soybean are commonly intercropped in the drier zones of the western mid-hills in
Nepal, but farmers report that productivity of soybean has been declining in recent years. …