SIMIAN immunodeficiency viruses have been isolated from four species of monkey, the 'captive'
macaque 1 and mangabey 2–4 and the 'feral' African green monkey 5 and mandrill 6 . …

Human immunodeficiency virus type 1 (HIV-1) eradication is prevented by the establishment
on infection of cellular HIV-1 reservoirs that are not fully characterized, especially in genital …

The tremendous dynamics of HIV infection finds expression in the tempo of sequence
diversification. Genetic diversity calculations require the clearance of a majority of infected cells, …

We studied T-cell reconstitution in 31 primary T-cell–immunodeficient patients who had
undergone hematopoietic stem-cell transplantation (HSCT) over 10 years previously. In 19 …

Despite efficient antiretroviral therapy (ART), CD4+ T cell counts often remain low in HIV-1-infected
patients. This has led to IL-7, a crucial cytokine involved in both thymopoiesis and …

Immune checkpoint inhibitors (ICI) have transformed the therapeutic landscape in oncology.
However, ICI can induce uncommon life-threatening autoimmune T-cell-mediated …

A genetic study has been made of the HIV tat gene from sequential HIV-1 isolates and the
corresponding infected peripheral blood mononuclear cells. DNA was amplified by …

Abstract Analysis of immune reconstitution is of major importance in clinical settings such as
following bone marrow transplantation or during anti-retroviral treatment of HIV-infected …

The supply of naive T cells by the thymus normally requires precursor T cell proliferation
within the thymus and would be particularly important in the setting of HIV infection when both …

Background Long-term immune recovery in older patients given hematopoietic cell transplantation
after non-myeloablative conditioning remains poorly understood. This prompted us to …