User profiles for Pranjal Biswas
 | Pranjal BiswasCleveland Clinic Verified email at ccf.org Cited by 270 |
Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH-and Hsp90-dependent control of their heme levels
Indoleamine-2, 3-dioxygenase (IDO1) and Tryptophan-2, 3-dioxygense (TDO) are heme-containing
dioxygenases that catalyze the conversion of tryptophan to N-formyl-kynurenine and …
dioxygenases that catalyze the conversion of tryptophan to N-formyl-kynurenine and …
[HTML][HTML] Nitric Oxide Production by Necrotrophic Pathogen Macrophomina phaseolina and the Host Plant in Charcoal Rot Disease of Jute: Complexity of the Interplay …
M. phaseolina, a global devastating necrotrophic fungal pathogen causes charcoal rot
disease in more than 500 host plants. With the aim of understanding the plant-necrotrophic …
disease in more than 500 host plants. With the aim of understanding the plant-necrotrophic …
The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression
The human apurinic/apyrimidinic endonuclease 1 (APE1) is a pleiotropic nuclear protein
with roles in DNA base excision repair pathway as well as in regulation of transcription. …
with roles in DNA base excision repair pathway as well as in regulation of transcription. …
New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals
The intracellular trafficking of mitochondrial heme presents a fundamental challenge to animal
cells. This article provides some background on heme allocation, discusses some of the …
cells. This article provides some background on heme allocation, discusses some of the …
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution
A natural heme deficiency that exists in cells outside of the circulation broadly compromises
the heme contents and functions of heme proteins in cells and tissues. Recently, we found …
the heme contents and functions of heme proteins in cells and tissues. Recently, we found …
[HTML][HTML] Functional maturation of cytochromes P450 3A4 and 2D6 relies on GAPDH-and Hsp90-Dependent heme allocation
Cytochrome P450 3A4 and 2D6 (EC 1.14.13.97 and 1.14.14.1; CYP3A4 and 2D6) are heme-containing
enzymes that catalyze the oxidation of a wide number of xenobiotic and drug …
enzymes that catalyze the oxidation of a wide number of xenobiotic and drug …
[HTML][HTML] Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase
Myoglobin (Mb) maturation involves heme incorporation as a final step. We investigated a
role for heat shock protein (hsp) 90 in Mb maturation in C2C12 skeletal muscle myoblasts and …
role for heat shock protein (hsp) 90 in Mb maturation in C2C12 skeletal muscle myoblasts and …
Targeting histone chaperone FACT complex overcomes 5-fluorouracil resistance in colon cancer
Fluorouracil (5-FU) remains a first-line chemotherapeutic agent for colorectal cancer.
However, a subset of colorectal cancer patients who have defective mismatch-repair (dMMR) …
However, a subset of colorectal cancer patients who have defective mismatch-repair (dMMR) …
Regulation of cell cycle and stress responses under nitrosative stress in Schizosaccharomyces pombe
Nitric oxide (NO) acts as a signaling molecule in numerous physiological processes but excess
production generates nitrosative stress in cells. The exact protective mechanism used by …
production generates nitrosative stress in cells. The exact protective mechanism used by …
[HTML][HTML] Visualizing mitochondrial heme flow through GAPDH in living cells and its regulation by NO
P Biswas, J Palazzo, S Schlanger, DT Jayaram, S Islam… - Redox Biology, 2024 - Elsevier
Iron protoporphyrin IX (heme) is a redox-active cofactor that is bound in mammalian cells by
GAPDH and allocated by a process influenced by physiologic levels of NO. This impacts the …
GAPDH and allocated by a process influenced by physiologic levels of NO. This impacts the …