Hematopoietic stem cells (HSCs) rely on complex regulatory networks to preserve stemness.
Due to the scarcity of HSCs, technical challenges have limited our insights into the interplay …

Adult hematopoietic stem and progenitor cells (HSPCs) respond directly to inflammation
and infection, causing both acute and persistent changes to quiescence, mobilization, and …

The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic
endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The …

RNA-Seq is now a routinely employed assay to measure gene expression. As the technique
matured over the last decade, so have dedicated analytic tools. In this chapter, we first …

The Yolk Sac (YS) and Aorta-Gonad-Mesonephros (AGM) are two major haematopoietic
regions during embryonic development. Interestingly, AGM is the only one generating …

The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic
endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The …

Blood as connective tissue potentially contains evidence of all processes occurring within
the organism, at least in trace amounts (Petricoin et al., 2006) [1]. Because of their small size, …

Adult hematopoietic stem and progenitor cells (HSPCs) respond directly to inflammation and
infection, resulting in both acute and persistent changes to quiescence, mobilization, and …

Background: Stromal cells, including CAFs, are a heterogeneous group of cells in the tumor
microenvironment. Many models describe their heterogeneity like the classification into 3 …

Hematopoietic stem cells (HSCs) hold the unique capacity to long-term reconstitute the entire
blood system. Metabolic, epigenetic and transcriptional drivers form complex regulatory …