Host-cell cysteine proteases play an essential role in the processing of the viral spike protein
of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases …

Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a
promising drug target for novel antivirals against SARS-CoV-2. The marine natural product …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to human
health and lacks an effective treatment. There is an urgent need for both real-time tracking …

Surface ligands play a critical role in controlling and defining the properties of colloidal
nanocrystals. These aspects have been exploited to design nanoparticle aggregation-based …

Activatable contrast agents are of ongoing research interest because they offer low background
and high specificity to the imaging target. Engineered sensitivity to protease activity is …

Plasmonic coupling via nanoparticle assembly is a popular signal-generation method in
bioanalytical sensors. Here, we customized an all-peptide-based ligand that carries an …

Aromatic interactions are commonly involved in the assembly of naturally occurring building
blocks, and these interactions can be replicated in an artificial setting to produce functional …

The identity and biological activity of most metabolites still remain unknown. A bottleneck in
the exploration of metabolite structures and pharmaceutical activities is the compound …

The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands
novel direct antiviral treatments. The main protease (M pro ) and papain-like protease (…

The main protease (M pro ) and papain‐like protease (PL pro ) play critical roles in SARS‐CoV‐2
replication and are promising targets for antiviral inhibitors. The simultaneous …