[PDF][PDF] MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
…, B Guo, SJ Wait, KB Spainhower, CC Conley, OS Chen… - Cancer cell, 2020 - cell.com
Small cell lung cancer (SCLC) is a neuroendocrine tumor treated clinically as a single
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based on …
disease with poor outcomes. Distinct SCLC molecular subtypes have been defined based on …
[HTML][HTML] CCC1 is a transporter that mediates vacuolar iron storage in yeast
L Li, OS Chen, DMV Ward, J Kaplan - Journal of Biological Chemistry, 2001 - ASBMB
The budding yeast Saccharomyces cerevisiae can grow for generations in the absence of
exogenous iron, indicating a capacity to store intracellular iron. As cells can accumulate iron …
exogenous iron, indicating a capacity to store intracellular iron. As cells can accumulate iron …
[HTML][HTML] Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis
A Kumánovics, OS Chen, L Li, D Bagley… - Journal of Biological …, 2008 - ASBMB
The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive
transcription factor Aft1 in regulating the expression of the iron transport system in …
transcription factor Aft1 in regulating the expression of the iron transport system in …
[HTML][HTML] Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis
OS Chen, RJ Crisp, M Valachovic, M Bard… - Journal of Biological …, 2004 - ASBMB
Saccharomyces cerevisiae responds to iron deprivation by increased transcription of the
iron regulon, including the high affinity cell-surface transport system encoded by FET3 and …
iron regulon, including the high affinity cell-surface transport system encoded by FET3 and …
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
M Gu, D LaJoie, OS Chen… - Proceedings of the …, 2017 - National Acad Sciences
Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been
implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in fission …
implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in fission …
Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis
OS Chen, S Hemenway… - Proceedings of the …, 2002 - National Acad Sciences
Decreased expression of Yfh1p in the budding yeast, Saccharomyces cerevisiae, and the
orthologous human gene frataxin results in respiratory deficiency and mitochondrial iron …
orthologous human gene frataxin results in respiratory deficiency and mitochondrial iron …
[PDF][PDF] Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver
OS Chen, KL Schalinske, RS Eisenstein - The Journal of nutrition, 1997 - researchgate.net
Iron regulatory protein 1 (IRP1) and IRP2 are cytoplasmic RNA binding proteins that coordinate
cellular iron homeostasis in mammals. We investigated the effect of dietary iron intake on …
cellular iron homeostasis in mammals. We investigated the effect of dietary iron intake on …
[HTML][HTML] CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation
OS Chen, J Kaplan - Journal of Biological Chemistry, 2000 - ASBMB
Deletion of YFH1 inSaccharomyces cerevisiae leads to a loss of respiratory competence due
to excessive mitochondrial iron accumulation. A suppressor screen identified a gene, CCC1…
to excessive mitochondrial iron accumulation. A suppressor screen identified a gene, CCC1…
[HTML][HTML] Iron differentially stimulates translation of mitochondrial aconitase and ferritin mRNAs in mammalian cells: implications for iron regulatory proteins as …
KL Schalinske, OS Chen, RS Eisenstein - Journal of Biological Chemistry, 1998 - ASBMB
Utilization of mRNAs containing iron-responsive elements (IREs) is modulated by iron-regulated
RNA-binding proteins (iron regulatory proteins). We examine herein whether iron …
RNA-binding proteins (iron regulatory proteins). We examine herein whether iron …
The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites
KL Schalinske, SA Anderson, PT Tuazon, OS Chen… - Biochemistry, 1997 - ACS Publications
Iron regulatory protein 1 (IRP1) modulates iron metabolism by binding to mRNAs encoding
proteins involved in the uptake, storage, and metabolic utilization of iron. Iron regulates IRP1 …
proteins involved in the uptake, storage, and metabolic utilization of iron. Iron regulates IRP1 …