Peptide-based vaccines: current progress and future challenges

RJ Malonis, JR Lai, O Vergnolle - Chemical reviews, 2019 - ACS Publications
Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Characterization of human glutaredoxin 2 as iron–sulfur protein: a possible role as redox sensor

CH Lillig, C Berndt, O Vergnolle… - Proceedings of the …, 2005 - National Acad Sciences
Human mitochondrial glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase (active
site: Cys-Ser-Tyr-Cys) that facilitates the maintenance of mitochondrial redox …

[PDF][PDF] A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

…, RH Bortz, AS Wirchnianski, G Lasso, O Vergnolle… - Cell host & …, 2020 - cell.com
There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19.
Rapid SARS-CoV-2 countermeasure development is contingent on the availability of robust, …

Efficacy and safety of COVID-19 convalescent plasma in hospitalized patients: a randomized clinical trial

…, NH Patel, L Cleare, O Vergnolle… - JAMA internal …, 2022 - jamanetwork.com
Importance There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in
patients hospitalized with COVID-19. Objective To determine the safety and efficacy of CCP …

Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation

L Favrot, JS Blanchard, O Vergnolle - Biochemistry, 2016 - ACS Publications
The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that
includes more than 100000 members among eukaryotes and prokaryotes. Acetylation …

Characterization of the SARS-CoV-2 S protein: biophysical, biochemical, structural, and antigenic analysis

…, RJ Malonis, JH Lee, K Tong, O Vergnolle… - ACS …, 2020 - ACS Publications
Coronavirus disease 2019 (COVID-19) is a global health crisis caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there is a critical need to …

[PDF][PDF] Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever

…, DP Maurer, AS Herbert, AS Wirchnianski, O Vergnolle… - Cell, 2021 - cell.com
Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority
pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific …

A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

…, K Tong, CG Rappazzo, G Lasso, O Vergnolle… - Mbio, 2021 - Am Soc Microbiol
Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the
FDA for emergency use, inhibit viral infection by targeting the receptor-binding domain (RBD) …

[HTML][HTML] Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC

…, JM Fels, K Tong, MC Mariano, O Vergnolle… - JCI insight, 2021 - ncbi.nlm.nih.gov
Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2)
antibodies (CCP) may hold promise as a treatment for coronavirus disease 2019 (COVID-19). …

Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice

JC Frei, AS Wirchnianski, J Govero, O Vergnolle… - Journal of …, 2018 - Am Soc Microbiol
Dengue virus is the most globally prevalent mosquito-transmitted virus. Primary infection with
one of four cocirculating serotypes (DENV-1 to -4) causes a febrile illness, but secondary …