[HTML][HTML] Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

…, RLM Faull, MA Curtis, HJ Waldvogel, OW Choi… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …

[HTML][HTML] The cerebellum ages slowly according to the epigenetic clock

S Horvath, V Mah, AT Lu, JS Woo, OW Choi… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Studies that elucidate why some human tissues age faster than others may shed light on
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …

The genome of the vervet (Chlorocebus aethiops sabaeus)

…, N Tran, Y Huang, V Ramensky, O Choi… - Genome …, 2015 - genome.cshlp.org
We describe a genome reference of the African green monkey or vervet (Chlorocebus
aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for …

Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits

AJ Jasinska, S Service, O Choi… - Human molecular …, 2009 - academic.oup.com
Genome-wide gene expression studies may provide substantial insight into gene activities
and biological pathways differing between tissues and individuals. We investigated such …

DNA methylation networks underlying mammalian traits

…, AS Chavez, H Chen, K Cheng, P Chiavellini, OW Choi… - Science, 2023 - science.org
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …

[HTML][HTML] Epigenetic clock and methylation studies in vervet monkeys

…, MJ Jorgensen, JA Mattison, K Wojta, OW Choi… - GeroScience, 2022 - Springer
DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …

Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate

…, SK Service, CB Peterson, RM Cantor, OW Choi… - Nature …, 2017 - nature.com
By analyzing multitissue gene expression and genome-wide genetic variation data in samples
from a vervet monkey pedigree, we generated a transcriptome resource and produced …

[HTML][HTML] Finding disease candidate genes by liquid association

…, S Yuan, D Bronnikov, D Chen, X Wei, OW Choi… - Genome biology, 2007 - Springer
Oi-Wa Choi … Saarela J, Kallio SP, Chen D, Montpetit A, Jokiaho A, Choi E, Asselta R,
Bronnikov D, Lincoln MR, Sadovnick AD, et al: PRKCA and multiple sclerosis: association in …

Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder

…, J DeYoung, M Almonte, OW Choi… - American Journal of …, 2009 - Wiley Online Library
We reported previously a significant linkage signal between psychotic bipolar disorder (BP)
and microsatellite markers on chromosome 5q31–34 in the National Institute of Mental …

A non-human primate system for large-scale genetic studies of complex traits

AJ Jasinska, MK Lin, S Service, OW Choi… - Human molecular …, 2012 - academic.oup.com
Non-human primates provide genetic model systems biologically intermediate between
humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (…