[HTML][HTML] Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
…, RLM Faull, MA Curtis, HJ Waldvogel, OW Choi… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …
[HTML][HTML] The cerebellum ages slowly according to the epigenetic clock
S Horvath, V Mah, AT Lu, JS Woo, OW Choi… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Studies that elucidate why some human tissues age faster than others may shed light on
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …
The genome of the vervet (Chlorocebus aethiops sabaeus)
…, N Tran, Y Huang, V Ramensky, O Choi… - Genome …, 2015 - genome.cshlp.org
We describe a genome reference of the African green monkey or vervet (Chlorocebus
aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for …
aethiops). This member of the Old World monkey (OWM) superfamily is uniquely valuable for …
Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits
AJ Jasinska, S Service, O Choi… - Human molecular …, 2009 - academic.oup.com
Genome-wide gene expression studies may provide substantial insight into gene activities
and biological pathways differing between tissues and individuals. We investigated such …
and biological pathways differing between tissues and individuals. We investigated such …
DNA methylation networks underlying mammalian traits
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …
[HTML][HTML] Epigenetic clock and methylation studies in vervet monkeys
…, MJ Jorgensen, JA Mattison, K Wojta, OW Choi… - GeroScience, 2022 - Springer
DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate
…, SK Service, CB Peterson, RM Cantor, OW Choi… - Nature …, 2017 - nature.com
By analyzing multitissue gene expression and genome-wide genetic variation data in samples
from a vervet monkey pedigree, we generated a transcriptome resource and produced …
from a vervet monkey pedigree, we generated a transcriptome resource and produced …
[HTML][HTML] Finding disease candidate genes by liquid association
…, S Yuan, D Bronnikov, D Chen, X Wei, OW Choi… - Genome biology, 2007 - Springer
… Oi-Wa Choi … Saarela J, Kallio SP, Chen D, Montpetit A, Jokiaho A, Choi E, Asselta R,
Bronnikov D, Lincoln MR, Sadovnick AD, et al: PRKCA and multiple sclerosis: association in …
Bronnikov D, Lincoln MR, Sadovnick AD, et al: PRKCA and multiple sclerosis: association in …
Polymorphisms in the GRIA1 gene region in psychotic bipolar disorder
…, J DeYoung, M Almonte, OW Choi… - American Journal of …, 2009 - Wiley Online Library
We reported previously a significant linkage signal between psychotic bipolar disorder (BP)
and microsatellite markers on chromosome 5q31–34 in the National Institute of Mental …
and microsatellite markers on chromosome 5q31–34 in the National Institute of Mental …
A non-human primate system for large-scale genetic studies of complex traits
AJ Jasinska, MK Lin, S Service, OW Choi… - Human molecular …, 2012 - academic.oup.com
Non-human primates provide genetic model systems biologically intermediate between
humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (…
humans and other mammalian model organisms. Populations of Caribbean vervet monkeys (…