m6A RNA methylation, a new hallmark in virus-host interactions

M Brocard, A Ruggieri, N Locker - Journal of General …, 2017 - microbiologyresearch.org
The role of m 6 A methylation of RNA has remained elusive for decades, but recent
technological advances are now allowing the mapping of the m 6 A methylation landscape at …

Flavivirus infection uncouples translation suppression from cellular stress responses

…, V Lohmann, R Bartenschlager, OT Fackler, N Locker… - MBio, 2017 - Am Soc Microbiol
As obligate parasites, viruses strictly depend on host cell translation for the production of
new progeny, yet infected cells also synthesize antiviral proteins to limit virus infection. …

A little less aggregation a little more replication: Viral manipulation of stress granules

MJ Brownsword, N Locker - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
Recent exciting studies have uncovered how membrane‐less organelles, also known as
biocondensates, are providing cells with rapid response pathways, allowing them to re‐…

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

…, RE George, WG Richards, KK Wong, N Locker… - Nature, 2018 - nature.com
N 6 -methyladenosine (m 6 A) modification of mRNA is emerging as an important regulator of
gene expression that affects different developmental and biological processes, and altered …

Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation

…, MKH Tung, MD Panas, G McInerney, N Locker… - Elife, 2019 - elifesciences.org
10.7554/eLife.46681.001 Knowledge of the host factors required for norovirus replication
has been hindered by the challenges associated with culturing human noroviruses. We have …

[HTML][HTML] Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation

…, R Parker, IG Goodfellow, A Ruggieri, N Locker - PLoS …, 2020 - journals.plos.org
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly
deploy defence mechanisms by shutting off the protein synthesis machinery and triggering …

Circularization of flavivirus genomic RNA inhibits de novo translation initiation

…, HV Mears, T Fajardo Jr, N Locker… - Nucleic acids …, 2019 - academic.oup.com
Members of the Flaviviridae family, including dengue virus (DENV) and yellow fever virus,
cause serious disease in humans, whilst maternal infection with Zika virus (ZIKV) can induce …

HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly

N Locker, LE Easton, PJ Lukavsky - The EMBO journal, 2007 - embopress.org
Internal ribosome entry site (IRES) RNAs from the hepatitis C virus (HCV) and classical
swine fever virus (CSFV) coordinate cap‐independent assembly of eukaryotic 48S initiation …

Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growth

PN Huang, JY Lin, N Locker, YA Kung… - Nucleic acids …, 2011 - academic.oup.com
Enterovirus 71 (EV71) is associated with severe neurological disorders in children, and has
been implicated as the infectious agent in several large-scale outbreaks with mortalities. …

[HTML][HTML] Translational control during calicivirus infection

E Royall, N Locker - Viruses, 2016 - mdpi.com
In this review, we provide an overview of the strategies developed by caliciviruses to subvert
or regulate the host protein synthesis machinery to their advantage. As intracellular obligate …