Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased
susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient …

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived …

Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of allergic …

Toll-like receptors (TLRs) are crucial in the innate immune response to pathogens, in that
they recognize and respond to pathogen associated molecular patterns, which leads to …

Rhinoviruses cause serious morbidity and mortality as the major etiological agents of
asthma exacerbations and the common cold. A major obstacle to understanding disease …

Viral immune evasion strategies target key aspects of the host antiviral response. Recently,
it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against …

Rhinoviruses (RVs), which are the most common cause of virally induced asthma
exacerbations, account for much of the burden of asthma in terms of morbidity, mortality, and …

The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I
and MDA5 in viral infection is much debated. We investigated the roles of each pattern …

… Nathan W Bartlett was inadvertently omitted from the author list and the Contributions
section. The errors have been corrected in the HTML and PDF versions of the article. …

Asthma remains an important human disease that is responsible for substantial worldwide
morbidity and mortality. The causes of asthma are multifactorial and include a complex mix of …