Aquaporin (AQP) water channels, essential for fluid homeostasis, are expressed in
perivascular brain end-feet regions of astroglia (AQP4) and in choroid plexus (AQP1). At a high …

In order to improve the discovery and development of new drugs, a broad effort is being
made to assess the ‘drug-like’ properties of molecules in early stages of the discovery-research …

DNA hypomethylating drugs that act on DNA methyltransferase (DNMT) isoforms are
promising anticancer agents. By using a well‐characterized live‐cell system to measure DNA …

These results highlight the dependence of MM on IKZF1-bound super-enhancers, which
can be effectively targeted by a potent therapeutic combination pairing IMiD-mediated …

Quiescin sulfhydryl oxidase 1 (QSOX1) is a highly conserved disulfide bond-generating
enzyme that is overexpressed in diverse tumor types. Its enzymatic activity promotes the growth …

Abnormally low plasma concentrations of thyroid hormones during sepsis often occur in the
absence of thyroidal illness; however, the mechanisms involved in the “euthyroid sick …

Seventy-six FDA-approved oncology drugs and emerging therapeutics were evaluated in 25
multiple myeloma (MM) and 15 non-Hodgkin’s lymphoma cell lines and in 113 primary MM …

Introduction: The concept of chemical space has broad applications in drug discovery. In
response to the needs of drug discovery campaigns, different approaches are followed to …

The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was
initially identified in an unbiased in vitro chemical library screen. The activity of APY0201 was …

Understanding how a gas is able to strongly insulate electric devices is certainly of great
importance to the electrical engineering community. More precisely, modeling how a dielectric …