User profiles for Mobina Khericha
 | Mobina Khericha, PhDUCLA Verified email at ucla.edu Cited by 670 |
Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
10.7554/eLife.10956.001 Women live on average longer than men but have greater levels
of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the …
of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the …
[PDF][PDF] Short-term, intermittent fasting induces long-lasting gut health and TOR-independent lifespan extension
Intermittent fasting (IF) can improve function and health during aging in laboratory model
organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila …
organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila …
[HTML][HTML] Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease
…, I Snoeren, HM Cocheme, J Adcott, M Khericha… - PLoS …, 2017 - journals.plos.org
Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for
the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current …
the prevention of neurodegenerative diseases, including Alzheimer’s disease (AD). Current …
[HTML][HTML] CAR-T cell manufacturing: Major process parameters and next-generation strategies
M Ayala Ceja, M Khericha, CM Harris… - Journal of Experimental …, 2024 - rupress.org
Chimeric antigen receptor (CAR)-T cell therapies have demonstrated strong curative potential
and become a critical component in the array of B-cell malignancy treatments. Successful …
and become a critical component in the array of B-cell malignancy treatments. Successful …
CD19/CD20 bispecific chimeric antigen receptor (CAR) in naive/memory T cells for the treatment of relapsed or refractory non-Hodgkin lymphoma
…, J Trent, JM Chen, M Roshandell, C Harris, M Khericha… - Cancer discovery, 2023 - AACR
Autologous CD19/CD20 bispecific CAR-T cell therapy generated from T N/MEM cells for
patients with NHL is safe (no neurotoxicity, maximum grade 1 cytokine release syndrome) and …
patients with NHL is safe (no neurotoxicity, maximum grade 1 cytokine release syndrome) and …
[HTML][HTML] Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease
…, I Rogers, L Li, P Martinez, M Khericha… - Frontiers in aging …, 2014 - frontiersin.org
The greatest risk factor for Alzheimer's disease (AD) is age, and changes in the ageing
nervous system are likely contributors to AD pathology. Amyloid beta (Aβ) accumulation, which …
nervous system are likely contributors to AD pathology. Amyloid beta (Aβ) accumulation, which …
[PDF][PDF] Intestinal fork head regulates nutrient absorption and promotes longevity
E Bolukbasi, M Khericha, JC Regan, DK Ivanov… - Cell reports, 2017 - cell.com
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet
the underlying biology remains unclear. We show that the anti-aging effects of rapamycin …
the underlying biology remains unclear. We show that the anti-aging effects of rapamycin …
[HTML][HTML] pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity
O Sofola-Adesakin, M Khericha, I Snoeren… - Acta neuropathologica …, 2016 - Springer
Several species of β-amyloid peptides (Aβ) exist as a result of differential cleavage from
amyloid precursor protein (APP) to yield various C-terminal Aβ peptides. Several N-terminal …
amyloid precursor protein (APP) to yield various C-terminal Aβ peptides. Several N-terminal …
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells
…, YX Lu, E Bolukbasi, M Khericha… - Proceedings of the …, 2024 - National Acad Sciences
Pharmacological therapies are promising interventions to slow down aging and reduce
multimorbidity in the elderly. Studies in animal models are the first step toward translation of …
multimorbidity in the elderly. Studies in animal models are the first step toward translation of …
Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR
X Chen, LC Chen, M Khericha, X Meng… - Cancer immunology …, 2023 - AACR
… Mobina Khericha … Mobina Khericha … Chen, Mobina Khericha, Xiangzhi Meng, Emma
Salvestrini, Amanda Shafer, Neha Iyer, Anya S. Alag, Yunfeng Ding, Demetri M. Nicolaou, Yvonne Y. …
Salvestrini, Amanda Shafer, Neha Iyer, Anya S. Alag, Yunfeng Ding, Demetri M. Nicolaou, Yvonne Y. …