Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
MJ Workman, MM Mahe, S Trisno, HM Poling… - Nature medicine, 2017 - nature.com
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse
functions, including motility and epithelial permeability. Perturbations in ENS development or …
functions, including motility and epithelial permeability. Perturbations in ENS development or …
[PDF][PDF] Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications
The blood-brain barrier (BBB) tightly regulates the entry of solutes from blood into the brain
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …
and is disrupted in several neurological diseases. Using Organ-Chip technology, we created …
[PDF][PDF] Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
[HTML][HTML] Enhanced utilization of induced pluripotent stem cell–derived human intestinal organoids using microengineered chips
MJ Workman, JP Gleeson, EJ Troisi, HQ Estrada… - Cellular and molecular …, 2018 - Elsevier
… Image J analysis was used to quantify levels of phosphorylated STAT1 compared with …
Conflicts of interest These authors disclose the following: Michael J. Workman, Stephan R. …
Conflicts of interest These authors disclose the following: Michael J. Workman, Stephan R. …
Fe–N–C catalyst graphitic layer structure and fuel cell performance
For targeted development of platinum group metal-free (PGM-free) catalysts for proton
exchange membrane fuel cell applications, it is critically important to elucidate the catalytic …
exchange membrane fuel cell applications, it is critically important to elucidate the catalytic …
[PDF][PDF] Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects
Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological
disease holds great promise; however, there is a lack of well-curated lines from a large …
disease holds great promise; however, there is a lack of well-curated lines from a large …
PGM-free Fe-NC catalysts for oxygen reduction reaction: Catalyst layer design
This work studies the morphology of platinum group metal-free (PGM-free) iron-nitrogen-carbon
(Fe-NC) catalyst layers for the oxygen reduction reaction (ORR) and compares catalytic …
(Fe-NC) catalyst layers for the oxygen reduction reaction (ORR) and compares catalytic …
Highly stable precious metal-free cathode catalyst for fuel cell application
A platinum group metal-free (PGM-free) oxygen reduction reaction (ORR) catalyst engineered
for stability has been synthesized using the sacrificial support method (SSM). This catalyst …
for stability has been synthesized using the sacrificial support method (SSM). This catalyst …
[HTML][HTML] Recent advances in human iPSC-derived models of the blood–brain barrier
MJ Workman, CN Svendsen - Fluids and Barriers of the CNS, 2020 - Springer
The blood–brain barrier (BBB) is a critical component of the central nervous system that
protects neurons and other cells of the brain parenchyma from potentially harmful substances …
protects neurons and other cells of the brain parenchyma from potentially harmful substances …
Platinum group metal-free electrocatalysts: Effects of synthesis on structure and performance in proton-exchange membrane fuel cell cathodes
Abstract Development of platinum group metal free catalysts for the oxygen reduction reaction
(ORR) in proton exchange membrane fuel cells (PEMFCs) requires understanding of the …
(ORR) in proton exchange membrane fuel cells (PEMFCs) requires understanding of the …