[HTML][HTML] A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens

…, AD Stern, RJ Koch, MS DiStefano… - PLoS computational …, 2018 - journals.plos.org
Most cancer cells harbor multiple drivers whose epistasis and interactions with expression
context clouds drug and drug combination sensitivity prediction. We constructed a …

Drug response consistency in CCLE and CGP

M Bouhaddou, MS DiStefano, EA Riesel, E Carrasco… - Nature, 2016 - nature.com
The Cancer Cell Line Encyclopedia 1 (CCLE) and Cancer Genome Project 2 (CGP) are two
independent large-scale efforts to characterize genomes, mRNA expression, and anti-…

An integrated mechanistic model of pan-cancer driver pathways predicts stochastic proliferation and death

M Bouhaddou, AM Barrette, RJ Koch, MS DiStefano… - BioRxiv, 2017 - biorxiv.org
Most cancer cells harbor multiple drivers whose epistasis and interactions with expression
context clouds drug sensitivity prediction. We constructed a mechanistic computational model …

A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

…, AL Harmon, A Golie, J Hartzel, J Xu, S Li, H Matthews… - Vaccine, 2002 - Elsevier
This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine
and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12…

Production of antibodies and development of highly sensitive formats of enzyme immunoassay for saxitoxin analysis

…, S Di Stefano, D Moscone, G Palleschi, S Marini… - Analytical and …, 2002 - Springer
In this paper the production of antibodies against saxitoxin (STX) is described, as is the
optimization and comparison of two competitive ELISA formats (direct and indirect) for the …

Nearby Planetary Systems as Lenses during Predicted Close Passages to Background Stars

R Di Stefano, J Matthews, S Lépine - The Astrophysical Journal, 2013 - iopscience.iop.org
… To detect evidence of the planets, we must be sensitive to small deviations of the type studied
in Di Stefano (2012). The deviations have a characteristic up-down–up-down shape, and …

Reactivity of carbonyl and phosphoryl groups at calixarenes

R Cacciapaglia, S Di Stefano, L Mandolini… - Supramolecular …, 2013 - Taylor & Francis
Examples of reactivity of carbonyl and phosphoryl compounds controlled by calixarenes are
illustrated in this review article. The molecular framework of calixarenes has been widely …

Proximity Effects on the Reactivity of a Nonheme Iron (IV) Oxo Complex in C‐H Oxidation

…, O Lanzalunga, M Costas, S Di Stefano… - Angewandte …, 2024 - Wiley Online Library
Precise control of substrate positioning and orientation (its proximity to the reactive unit) is
often invoked to rationalize the superior enzymatic reaction rates and selectivities when …

Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice

…, EK Govek, T McDonagh, Y Qi, PS DiStefano… - Regulatory peptides, 2008 - Elsevier
Stimulation of the ghrelin receptor (GhrR) by ghrelin results in a variety of metabolic changes
including increased food intake, fat storage and insulin resistance. Loss of ghrelin signaling …

Functional characterization of Narc 1, a novel proteinase related to proteinase K

…, JS Jacobsen, JD Kennedy, PS DiStefano… - Archives of biochemistry …, 2003 - Elsevier
The NARC 1 gene encodes a novel proteinase K family proteinase. The domain structure of
rat Narc 1 resembles that of the subtilisin-like proprotein convertases (SPCs), except that …