[HTML][HTML] A mechanistic pan-cancer pathway model informed by multi-omics data interprets stochastic cell fate responses to drugs and mitogens
…, AD Stern, RJ Koch, MS DiStefano… - PLoS computational …, 2018 - journals.plos.org
Most cancer cells harbor multiple drivers whose epistasis and interactions with expression
context clouds drug and drug combination sensitivity prediction. We constructed a …
context clouds drug and drug combination sensitivity prediction. We constructed a …
Drug response consistency in CCLE and CGP
M Bouhaddou, MS DiStefano, EA Riesel, E Carrasco… - Nature, 2016 - nature.com
The Cancer Cell Line Encyclopedia 1 (CCLE) and Cancer Genome Project 2 (CGP) are two
independent large-scale efforts to characterize genomes, mRNA expression, and anti-…
independent large-scale efforts to characterize genomes, mRNA expression, and anti-…
An integrated mechanistic model of pan-cancer driver pathways predicts stochastic proliferation and death
M Bouhaddou, AM Barrette, RJ Koch, MS DiStefano… - BioRxiv, 2017 - biorxiv.org
Most cancer cells harbor multiple drivers whose epistasis and interactions with expression
context clouds drug sensitivity prediction. We constructed a mechanistic computational model …
context clouds drug sensitivity prediction. We constructed a mechanistic computational model …
A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children
…, AL Harmon, A Golie, J Hartzel, J Xu, S Li, H Matthews… - Vaccine, 2002 - Elsevier
This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine
and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12…
and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12…
Production of antibodies and development of highly sensitive formats of enzyme immunoassay for saxitoxin analysis
…, S Di Stefano, D Moscone, G Palleschi, S Marini… - Analytical and …, 2002 - Springer
In this paper the production of antibodies against saxitoxin (STX) is described, as is the
optimization and comparison of two competitive ELISA formats (direct and indirect) for the …
optimization and comparison of two competitive ELISA formats (direct and indirect) for the …
Nearby Planetary Systems as Lenses during Predicted Close Passages to Background Stars
R Di Stefano, J Matthews, S Lépine - The Astrophysical Journal, 2013 - iopscience.iop.org
… To detect evidence of the planets, we must be sensitive to small deviations of the type studied
in Di Stefano (2012). The deviations have a characteristic up-down–up-down shape, and …
in Di Stefano (2012). The deviations have a characteristic up-down–up-down shape, and …
Reactivity of carbonyl and phosphoryl groups at calixarenes
R Cacciapaglia, S Di Stefano, L Mandolini… - Supramolecular …, 2013 - Taylor & Francis
Examples of reactivity of carbonyl and phosphoryl compounds controlled by calixarenes are
illustrated in this review article. The molecular framework of calixarenes has been widely …
illustrated in this review article. The molecular framework of calixarenes has been widely …
Proximity Effects on the Reactivity of a Nonheme Iron (IV) Oxo Complex in C‐H Oxidation
Precise control of substrate positioning and orientation (its proximity to the reactive unit) is
often invoked to rationalize the superior enzymatic reaction rates and selectivities when …
often invoked to rationalize the superior enzymatic reaction rates and selectivities when …
Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice
…, EK Govek, T McDonagh, Y Qi, PS DiStefano… - Regulatory peptides, 2008 - Elsevier
Stimulation of the ghrelin receptor (GhrR) by ghrelin results in a variety of metabolic changes
including increased food intake, fat storage and insulin resistance. Loss of ghrelin signaling …
including increased food intake, fat storage and insulin resistance. Loss of ghrelin signaling …
Functional characterization of Narc 1, a novel proteinase related to proteinase K
…, JS Jacobsen, JD Kennedy, PS DiStefano… - Archives of biochemistry …, 2003 - Elsevier
The NARC 1 gene encodes a novel proteinase K family proteinase. The domain structure of
rat Narc 1 resembles that of the subtilisin-like proprotein convertases (SPCs), except that …
rat Narc 1 resembles that of the subtilisin-like proprotein convertases (SPCs), except that …