Foxl2 is a forkhead transcription factor essential for proper reproductive function in females.
Human patients carrying mutations in the FOXL2 gene display blepharophimosis/ptosis/…

Development of the anterior pituitary gland ultimately leads to the appearance of five distinct
cell types that are defined by the trophic hormones which they produce, providing an …

The role of the ubiquitin-dependent proteolysis system in c-Jun breakdown was investigated.
Using in vitro experiments and a novel in vivo assay that utilizes molecularly-tagged …

In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally responsible
for triggering the indifferent gonads to develop as testes rather than ovaries. However, …

Human Blepharophimosis/ptosis/epicanthus inversus syndrome (BPES) type I is an autosomal
dominant disorder associated with premature ovarian failure (POF)caused by mutations …

Since the discovery of the conserved forkhead (Fkh) DNA binding domain more than 20 years
ago, members of the Fkh or forkhead box (FOX) family of transcription factors have been …

The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a
number of inducers that act through mitogen-activated protein kinase (MAPK) signal …

During development of the mammalian pituitary gland specific hormone-producing cell types,
critical in maintaining homeostasis, emerge in a spatially and temporally specific fashion …

The mechanisms by which transient gradients of signaling molecules lead to emergence of
specific cell types remain a central question in mammalian organogenesis. Here, we …

Pituitary gland development serves as an excellent model system in which to study the
emergence of distinct cell types from a common primordium in mammalian organogenesis. We …