Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions through
incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r expression …

Podocytes are specialized epithelial cells of the kidney blood filtration barrier that contribute
to permselectivity via a series of interdigitating actin–rich foot processes. Positioned …

Traditionally, the evaluation of cardiac function has focused on systolic function; however,
there is a growing appreciation for the contribution of diastolic function to overall cardiac health…

A growing proportion of heart failure (HF) patients present with impairments in both ventricles.
Experimental pressure-overload (ie, transverse aortic constriction, TAC) induces left …

Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is
characterized by craniofacial, growth, cognitive and cardiac defects. NS patients with kinase-…

Background Maintenance of the kidney filtration barrier requires coordinated interactions
between podocytes and the underlying glomerular basement membrane (GBM). GBM ligands …

Diaphragmatic weakness is a feature of heart failure (HF) associated with dyspnea and
exertional fatigue. Most studies have focused on advanced stages of HF, leaving the cause …

Background Echocardiography is a valuable noninvasive technique to estimate cardiac
output (CO) from the left ventricle (LV) not only in clinical practice but also in small-animal …

The role of erythropoietin (EPO) has extended beyond hematopoiesis to include cytoprotection,
inotropy, and neurogenesis. Extra-renal EPO has been reported for multiple tissue/cell …

Dyspnea and reduced exercise capacity, caused, in part, by respiratory muscle dysfunction,
are common symptoms in patients with heart failure (HF). However, the etiology of …